Novel and improved biocatalysts are increasingly sourced from libraries via experimental
screening. The success of such campaigns is crucially dependent on the number of …

Single-cell genomic technologies are revealing the cellular composition, identities and
states in tissues at unprecedented resolution. They have now scaled to the point that it is …

Recent technological innovations have enabled the high-throughput quantification of gene
expression and epigenetic regulation within individual cells, transforming our understanding …

Droplet-based single-cell assays, including single-cell RNA sequencing (scRNA-seq),
single-nucleus RNA sequencing (snRNA-seq) and cellular indexing of transcriptomes and …

Single-cell genetic heterogeneity is ubiquitous in microbial populations and an important
aspect of microbial biology; however, we lack a broadly applicable and accessible method …

Although virus–host interactions are usually studied in a single cell type using in vitro assays
in immortalized cell lines or isolated cell populations, it is important to remember that what is …

Single-cell and spatial molecular profiling assays have shown large gains in sensitivity,
resolution and throughput. Applying these technologies to specimens from human and …

The CRISPR genome editing technology has revolutionized the way gene function is
studied. Genome editing can be achieved in single genes or for thousands of genes …

The development of sequencing methods has resulted in the investigation of many
unexplored research areas. Among the different sequencing methods, single-cell …

From “Lab on a Chip” to “Lab on a Particle”. The miniaturization and automation of life
science laboratory operations has leveraged fabrication advances in the integrated circuit …