Afferent and efferent cardiac neurotransmission via the cardiac nerves intricately modulates
nearly all physiological functions of the heart (chronotropy, dromotropy, lusitropy, and …

Cardiac control is mediated via a series of reflex control networks involving somata in the (i)
intrinsic cardiac ganglia (heart),(ii) intrathoracic extracardiac ganglia (stellate, middle …

Objective ANTHEM-HF evaluated a novel autonomic regulation therapy (ART) via either left
or right vagus nerve stimulation (VNS) in patients with heart failure (HF) and reduced …

Key points• Control of regional cardiac function, as mediated by the intrinsic cardiac (IC)
nervous system, is dependent upon its cardiac afferent neuronal inputs, changes in its …

The heart is a functional syncytium controlled by a delicate and sophisticated balance
ensured by the tight coordination of its several cell subpopulations. Accordingly …

This paper aims to determine whether chronic vagus nerve stimulation (VNS) mitigates
myocardial infarction (MI)-induced remodeling of the intrinsic cardiac nervous system …

Intrinsic cardiac neurons (ICNs) play a crucial role in the proper functioning of the heart; yet
a paucity of data pertaining to human ICNs exist. We took a multidisciplinary approach to …

Mediastinal nerve stimulation (MNS) reproducibly evokes atrial fibrillation (AF) by excessive
and heterogeneous activation of intrinsic cardiac (IC) neurons. This study evaluated whether …

Our objective was to determine whether chronic vagus nerve stimulation (VNS) mitigates
pressure overload (PO)-induced remodeling of the cardioneural interface. Guinea pigs (n …

Background Approximately half of the patients presenting with new‐onset heart failure (HF)
have HF with preserved left ventricular ejection fraction (HFpEF) and HF with mid‐range left …