Pathways and genes involved in steroid hormone metabolism in male pigs: A review and update

A Robic, T Faraut, A Prunier - The Journal of steroid biochemistry and …, 2014 - Elsevier
This paper reviews state-of-the-art knowledge on steroid biosynthesis pathways in the pig
and provides an updated characterization of the porcine genes involved in these pathways …

Comparative cytotoxic effects and possible mechanisms of deoxynivalenol, zearalenone and T-2 toxin exposure to porcine leydig cells in vitro

L Sun, J Dai, J Xu, J Yang, D Zhang - Toxins, 2022 - mdpi.com
Mycotoxins such as zearalenone (ZEN), deoxynivalenol (DON) and T-2 toxin (T-2) are the
most poisonous biological toxins in food pollution. Mycotoxin contaminations are a global …

Effects of defined mixtures of POPs and endocrine disruptors on the steroid metabolome of the human H295R adrenocortical cell line

KEM Ahmed, HG Frøysa, OA Karlsen, N Blaser… - Chemosphere, 2019 - Elsevier
The presence of environmental pollutants in our ecosystem may impose harmful health
effects to wildlife and humans. Several of these toxic chemicals have a potential to interfere …

Effects of novel brominated flame retardants on steroidogenesis in primary porcine testicular cells

R Mankidy, B Ranjan, A Honaramooz, JP Giesy - Toxicology letters, 2014 - Elsevier
Brominated flame retardants are chemicals with fire quenching properties which are
extensively used in manufacturing. Historically, less regulated use of legacy brominated …

Sirtuin 1-mediated autophagy regulates testosterone synthesis in Leydig cells of piglets

Y Zhang, L Yu, Y He, C Liu, MM Abouelfetouh, S Ju… - Theriogenology, 2024 - Elsevier
Testosterone is secreted by Leydig cells (LCs), which play an important physiological role in
preserving male secondary sex characteristics, protecting male reproductive function, and …

An investigation of the endocrine disrupting potential of enniatin B using in vitro bioassays

S Kalayou, D Ndossi, C Frizzell, PK Groseth… - Toxicology Letters, 2015 - Elsevier
Evidence that some of the fungal metabolites present in food and feed may act as potential
endocrine disruptors is increasing. Enniatin B (ENN B) is among the emerging Fusarium …

Exploration of steroidogenesis‐related genes in testes, ovaries, adrenals, liver and adipose tissue in pigs

A Robic, K Feve, I Louveau, J Riquet… - Animal science …, 2016 - Wiley Online Library
To explore the metabolism of steroids in the pig species, a qualitative PCR analysis was
performed for the main transcript of 27 genes involved in steroid metabolism. We compared …

Developmental changes in the role of gonadotropin-inhibitory hormone (GnIH) and its receptors in the reproductive axis of male **aomeishan pigs

L Zheng, J Su, R Fang, M **, Z Lei, Y Hou, Z Ma… - Animal Reproduction …, 2015 - Elsevier
Abstract Gonadotropin-inhibitory hormone (GnIH), a key regulator of vertebrate reproduction,
was identified in the Japanese quail in 2000, and RFamide-related peptide-3 (RFRP-3) was …

Pig StAR: mRNA expression and alternative splicing in testis and Leydig cells, and association analyses with testicular morphology traits

Y Zhang, Y Cui, X Zhang, Y Wang, J Gao, T Yu, X Lv… - Theriogenology, 2018 - Elsevier
Steroidogenic acute regulatory protein (StAR), primarily expressed in Leydig cells (LCs) in
the mammalian testes, is essential for testosterone biosynthesis and male fertility. However …

Pig Hsd17b3: Alternative splice variants expression, insertion/deletion (indel) in promoter region and their associations with male reproductive traits

M Chen, W Yang, N Liu, X Zhang, W Dong… - The Journal of steroid …, 2019 - Elsevier
Abstract Hydroxysteroid 17-Beta Dehydrogenase 3 (Hsd17b3), primarily expressed in
Leydig cells (LCs) of the mammalian testes, is essential for testosterone biosynthesis and …