Cells coordinate intracellular activities in response to changes in the extracellular
environment to maximize their probability of survival and proliferation. Eukaryotic cells need …

In response to osmotic dehydration cells sense, signal, alter gene expression, and
metabolically counterbalance osmotic differences. The main compatible solute/osmolyte that …

From bacteria to humans, individual cells within isogenic populations can show significant
variation in stress tolerance, but the nature of this heterogeneity is not clear. To investigate …

While fungi are widely occupying nature, many species are responsible for devastating
mycosis in humans. Such niche diversity explains how quick fungal adaptation is necessary …

Control of the G1/S phase transition by the Retinoblastoma (RB) tumor suppressor is critical
for the proliferation of normal cells in tissues, and its inactivation is one of the most …

Adaptation is essential for maximizing cell survival and for cell fitness in response to sudden
changes in the environment. Several aspects of cell physiology change during adaptation …

Upon environmental changes, proliferating cells delay cell cycle to prevent further damage
accumulation. Yeast Cip1 is a Cdk1 and Cln2-associated protein. However, the function and …

In budding yeast, overcoming of a critical size to enter S phase and the mitosis/mating switch—
two central cell fate events—take place in the G1 phase of the cell cycle. Here we present a …

Eukaryotic cells decide in late G1 phase of the cell cycle whether to commit to another round
of division. This point of cell cycle commitment is termed “Restriction Point” in mammals and …

Conflicts between replication and transcription machineries represent a major source of
genomic instability and cells have evolved strategies to prevent such conflicts. However …