Breast cancer is the leading cause of death among solid tumours in women, and its
incidence is increasing in the West. Adjuvant chemotherapy and hormonal treatment …

Dysregulation of normal programmed cell death mechanisms plays an important role in the
pathogenesis and progression of breast cancer, as well as in responses of tumors to …

Advances in genomics and proteomics are dramatically increasing the need to evaluate
large numbers of molecular targets for their diagnostic, predictive or prognostic value in …

The aim of this study was to evaluate the possible correlation between preoperative FDG-
PET results in human breast cancer and the prognostic markers Ki-67, c-erb B2, p53 …

Purpose: Prognostication of breast cancer using clinicopathologic variables, although
useful, remains imperfect. Many reports suggest that gene expression profiling can refine the …

Toxicity and resistance to newly synthesized anticancer drugs represent a challenging
phenomenon of intensified concern arising from variation in drug targets and consequently …

Aiming to develop multitarget drugs for the anticancer treatment, a new class of chalcone-
pyrrolo [2, 1-c][1, 4] benzodiazepine (PBD) conjugates linked through a 1, 2, 3-triazole …

Our objective was to investigate the prognostic significance of cell turnover (apoptosis and
proliferation) in breast cancer patients. Apoptosis was microscopically quantitated on …

Abstract p21 protein (p21) inhibitor of cyclin-dependent kinases is a critical downstream
effector in the p53-specific pathway of growth control and can also be induced by p53 …

Glycyrrhetinic acid (GA) is one of many interesting pentacyclic triterpenoids showing
significant anticancer activity by triggering apoptosis in tumor cell lines. This study deals with …