The molecular basis for cellular function of intrinsically disordered protein regions
Intrinsically disordered protein regions exist in a collection of dynamic interconverting
conformations that lack a stable 3D structure. These regions are structurally heterogeneous …
conformations that lack a stable 3D structure. These regions are structurally heterogeneous …
Intrinsically disordered protein regions and phase separation: sequence determinants of assembly or lack thereof.
Intrinsically disordered protein regions (IDRs)-regions that do not fold into a fixed three-
dimensional structure but instead exist in a heterogeneous ensemble of conformations-have …
dimensional structure but instead exist in a heterogeneous ensemble of conformations-have …
flDPnn: Accurate intrinsic disorder prediction with putative propensities of disorder functions
Identification of intrinsic disorder in proteins relies in large part on computational predictors,
which demands that their accuracy should be high. Since intrinsic disorder carries out a …
which demands that their accuracy should be high. Since intrinsic disorder carries out a …
Conformational ensembles of the human intrinsically disordered proteome
Intrinsically disordered proteins and regions (collectively, IDRs) are pervasive across
proteomes in all kingdoms of life, help to shape biological functions and are involved in …
proteomes in all kingdoms of life, help to shape biological functions and are involved in …
Intrinsically disordered regions are poised to act as sensors of cellular chemistry
Intrinsically disordered proteins and protein regions (IDRs) are abundant in eukaryotic
proteomes and play a wide variety of essential roles. Instead of folding into a stable …
proteomes and play a wide variety of essential roles. Instead of folding into a stable …
The material properties of a bacterial-derived biomolecular condensate tune biological function in natural and synthetic systems
Intracellular phase separation is emerging as a universal principle for organizing
biochemical reactions in time and space. It remains incompletely resolved how biological …
biochemical reactions in time and space. It remains incompletely resolved how biological …
Molecular and environmental determinants of biomolecular condensate formation
JA Villegas, M Heidenreich, ED Levy - Nature chemical biology, 2022 - nature.com
Biomolecular condensate formation has been implicated in a host of biological processes
and has found relevance in biology and disease. Understanding the physical principles and …
and has found relevance in biology and disease. Understanding the physical principles and …
Clustering of aromatic residues in prion-like domains can tune the formation, state, and organization of biomolecular condensates: published as part of the …
In immature oocytes, Balbiani bodies are conserved membraneless condensates implicated
in oocyte polarization, the organization of mitochondria, and long-term organelle and RNA …
in oocyte polarization, the organization of mitochondria, and long-term organelle and RNA …
Interactions by disorder–a matter of context
Living organisms depend on timely and organized interactions between proteins linked in
interactomes of high complexity. The recent increased precision by which protein …
interactomes of high complexity. The recent increased precision by which protein …
Direct prediction of intrinsically disordered protein conformational properties from sequence
Intrinsically disordered regions (IDRs) are ubiquitous across all domains of life and play a
range of functional roles. While folded domains are generally well-described by a stable 3D …
range of functional roles. While folded domains are generally well-described by a stable 3D …