Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation

JAHR Claassen, DHJ Thijssen… - Physiological …, 2021‏ - journals.physiology.org
Brain function critically depends on a close matching between metabolic demands,
appropriate delivery of oxygen and nutrients, and removal of cellular waste. This matching …

Neurovascular and cognitive dysfunction in hypertension: epidemiology, pathobiology, and treatment

C Iadecola, RF Gottesman - Circulation research, 2019‏ - ahajournals.org
Hypertension has emerged as a leading cause of age-related cognitive impairment. Long
known to be associated with dementia caused by vascular factors, hypertension has more …

Hypertension, neurodegeneration, and cognitive decline

A Pacholko, C Iadecola - Hypertension, 2024‏ - ahajournals.org
Elevated blood pressure is a well-established risk factor for age-related cognitive decline.
Long linked to cognitive impairment on vascular bases, increasing evidence suggests a …

The association between glymphatic system dysfunction and cognitive impairment in cerebral small vessel disease

J Tang, M Zhang, N Liu, Y Xue, X Ren… - Frontiers in aging …, 2022‏ - frontiersin.org
The mechanism of cognitive impairment in patients with cerebral small vessel disease
(CSVD) remains unknown. The glymphatic system dysfunction, which has been …

Cerebral small vessel disease: a review of the pathophysiological mechanisms

Y Hannawi - Translational Stroke Research, 2024‏ - Springer
Cerebral small vessel disease (cSVD) refers to the age-dependent pathological processes
involving the brain small vessels and leading to vascular cognitive impairment, intracerebral …

Cerebral blood flow changes during aging process and in cognitive disorders: a review

N Mokhber, A Shariatzadeh, A Avan… - The …, 2021‏ - journals.sagepub.com
We aimed to summarize the available evidence on cerebral blood flow (CBF) changes in
normal aging and common cognitive disorders. We searched PubMed for studies on CBF …

Small vessel disease is associated with altered cerebrovascular pulsatility but not resting cerebral blood flow

Y Shi, MJ Thrippleton, GW Blair… - Journal of Cerebral …, 2020‏ - journals.sagepub.com
Cerebral small vessel disease (SVD) contributes to 25% of ischemic strokes and 45% of
dementias. We aimed to investigate the role of cerebral blood flow (CBF) and intracranial …

Common genetic variation indicates separate causes for periventricular and deep white matter hyperintensities

NJ Armstrong, KA Mather, M Sargurupremraj, MJ Knol… - Stroke, 2020‏ - ahajournals.org
Background and Purpose: Periventricular white matter hyperintensities (WMH; PVWMH) and
deep WMH (DWMH) are regional classifications of WMH and reflect proposed differences in …

Impact of stress and hypertension on the cerebrovasculature

N Elsaid, A Saied, H Kandil, A Soliman… - Frontiers in …, 2021‏ - zuscholars.zu.ac.ae
Objectives: Both stress and hypertension (HTN) are considered major health problems that
negatively impact the cerebral vasculature. In this article we summarize the possible …

Risk factors for ischemic stroke: differences between cerebral small vessel and large artery atherosclerosis aetiologies

Y Shi, L Guo, Y Chen, Q **e, Z Yan, Y Liu… - Folia …, 2021‏ - termedia.pl
The treatment for large artery atherosclerosis (LAA) stroke is also important for patients with
cerebral small vessel disease (SVD). Our aim is to clarify the risk factors for ischemic …