Genomic instability is the hallmark of various cancers with the increasing accumulation of
DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is …

Apoptosis, also named programmed cell death, is a fundament process required for
morphogenetic homeostasis during early development and in pathophysiological …

Cadmium is a heavy toxic metal with unknown biological functions in the human body. Over
time, cadmium accretion in the different visceral organs (liver, lungs, kidney, and testis) is …

Neurodegenerative disorders affect almost 30 million individuals leading to disability and
death. These disorders are characterized by pathological changes in disease-specific areas …

Since the initial description of apoptosis, a number of different forms of cell death have been
described. In this review we will focus on classic caspase-dependent apoptosis and its …

Significance: The molecular machinery regulating autophagy has started becoming
elucidated, and a number of studies have undertaken the task to determine the role of …

Cell death plays an important role in the regulation of inflammation and may be the result of
inflammation. The maintenance of tissue homeostasis necessitates both the recognition and …

Despite enormous advancements in the field of oncology, the innocuous and effectual
treatment of various types of malignancies remained a colossal challenge. The conventional …

Eukaryotic mitochondria resulted from symbiotic incorporation of α-proteobacteria into
ancient archaea species. During evolution, mitochondria lost most of the prokaryotic …

Apoptosis, an essential and basic biological phenomenon, is regulated in a complex
manner by a multitude of factors. Myeloid cell leukemia 1 (Mcl-1), an anti-apoptotic member …