While ventricular electromechanics is extensively studied in both physiological and
pathological conditions, four-chamber heart models have only been addressed recently; …

The growing global prevalence of heart failure (HF) necessitates innovative methods for
early diagnosis and classification of myocardial dysfunction. In recent decades, non-invasive …

Numerical simulations are ubiquitous in mathematics and computational science. Several
industrial and clinical applications entail modeling complex multiphysics systems that evolve …

The complicated interaction between a fluid flow and a deformable structure is referred to as
fluid–structure interaction (FSI). FSI plays a crucial role in the functioning of the aortic valve …

The recruitment of patients for rare or complex cardiovascular diseases is a bottleneck for
clinical trials and digital twins of the human heart have recently been proposed as a viable …

Computational fluid dynamics (CFD) is an important tool for the simulation of the
cardiovascular function and dysfunction. Due to the complexity of the anatomy, the …

We introduce a multiphysics and geometric multiscale computational model, suitable to
describe the hemodynamics of the whole human heart, driven by a four-chamber …

Background Simulating the cardiac function requires the numerical solution of multi-physics
and multi-scale mathematical models. This underscores the need for streamlined, accurate …

Disruptions to left atrial (LA) blood flow, such as those caused by atrial fibrillation (AF), can
lead to thrombosis in the left atrial appendage (LAA) and an increased risk of systemic …

In this work, we performed a computational image-based study of blood dynamics in the
whole left heart, both in a healthy subject and in a patient with mitral valve regurgitation. We …