Mass spectrometry for neurosurgery: Intraoperative support in decision‐making

SI Pekov, DS Bormotov, SI Bocharova… - Mass Spectrometry …, 2025 - Wiley Online Library
Ambient ionization mass spectrometry was proved to be a powerful tool for oncological
surgery. Still, it remains a translational technique on the way from laboratory to clinic. Brain …

Modern machine‐learning applications in ambient ionization mass spectrometry

AA Sorokin, SI Pekov, DS Zavorotnyuk… - Mass Spectrometry …, 2025 - Wiley Online Library
This article provides a comprehensive overview of the applications of methods of machine
learning (ML) and artificial intelligence (AI) in ambient ionization mass spectrometry (AIMS) …

Aggregation of Multimodal ICE-MS Data into Joint Classifier Increases Quality of Brain Cancer Tissue Classification

AA Sorokin, DS Bormotov, DS Zavorotnyuk, VA Eliferov… - Data, 2022 - mdpi.com
Mass spectrometry fingerprinting combined with multidimensional data analysis has been
proposed in surgery to determine if a biopsy sample is a tumor. In the specific case of brain …

Lipid Profiles of Human Brain Tumors Obtained by High-Resolution Negative Mode Ambient Mass Spectrometry

DS Zavorotnyuk, SI Pekov, AA Sorokin, DS Bormotov… - Data, 2021 - mdpi.com
Alterations in cell metabolism, including changes in lipid composition occurring during
malignancy, are well characterized for various tumor types. However, a significant part of …

All ions must serve: The role of various regimes of data acquisition in joint classifier for intraoperative mass spectrometry-based glial tumour identification

SI Pekov, DS Zavorotnyuk, AA Sorokin… - …, 2023 - f1000research.com
Background: Ambient ionisation mass spectrometry, in combination with machine learning
techniques, provides a promising tool for rapid intraoperative tumour tissue identification …

Determination of Brain Tissue Samples Storage Conditions for Reproducible Intraoperative Lipid Profiling

SI Pekov, ES Zhvansky, VA Eliferov, AA Sorokin… - Molecules, 2022 - mdpi.com
Ex-vivo molecular profiling has recently emerged as a promising method for intraoperative
tissue identification, especially in neurosurgery. The short-term storage of resected samples …

Shapley Value as a Quality Control for Mass Spectra of Human Glioblastoma Tissues

DS Zavorotnyuk, AA Sorokin, SI Pekov, DS Bormotov… - Data, 2023 - mdpi.com
The automatic processing of high-dimensional mass spectrometry data is required for the
clinical implementation of ambient ionization molecular profiling methods. However …

[HTML][HTML] Прецизионная медицина в онкологии: роль и перспективы масс-спектрометрии

ЕС Хмелевская, ЕА Перина, ЕЕ Буйко… - Бюллетень …, 2024 - cyberleninka.ru
Цель исследования–анализ накопленных данных о применении методов масс-
спектрометрии в диагностике, лечении и прогнозировании течения онкологических …

[HTML][HTML] COMPARISON OF LIPID ALTERATIONS IN ASTROCYTOMAS WITH INCREASING GRADE

SI Pekov, KV Bocharov, DS Bormotov… - Bulletin of Russian …, 2024 - cyberleninka.ru
The use of ambient ionization mass spectrometry methods is one of the promising
approaches to the impovement of glial tumor resection completeness by using an additional …

[PDF][PDF] Neomorphic IDH Heterodimer Mutants: An Underestimated Point in Cancer Pathogenesis

OV Dorovatovskaia, MY Oliferenko, AA Sorokin… - Current cancer drug … - researchgate.net
Mutations in an essential metabolic enzyme, isocitrate dehydrogenase (IDH), were found in
many cancers. The impact of IDH1 and IDH2 proteoforms mutations can vary and depend on …