Genetics and the placebo effect: the placebome
Placebos are indispensable controls in randomized clinical trials (RCTs), and placebo
responses significantly contribute to routine clinical outcomes. Recent neurophysiological …
responses significantly contribute to routine clinical outcomes. Recent neurophysiological …
The genetic basis of addictive disorders
F Ducci, D Goldman - Psychiatric Clinics, 2012 - psych.theclinics.com
• Genetic and environmental influences modulating risk of substance use disorders change
developmentally and across the lifespan.• Genes involved in vulnerability to addictions …
developmentally and across the lifespan.• Genes involved in vulnerability to addictions …
Estrogen signaling in Alzheimer's disease: molecular insights and therapeutic targets for Alzheimer's dementia
Estrogens play a crucial physiological function in the brain; however, debates exist
concerning the role of estrogens in Alzheimer's disease (AD). Women during pre-, peri-, or …
concerning the role of estrogens in Alzheimer's disease (AD). Women during pre-, peri-, or …
Living in the moment: effects of time perspective and emotional valence of episodic thinking on delay discounting.
H Lin, LH Epstein - Behavioral neuroscience, 2014 - psycnet.apa.org
Excessive delay discounting (DD) has been related to various maladaptive behaviors and
may stem from a myopic focus on immediate gratification. Neuroimaging studies have …
may stem from a myopic focus on immediate gratification. Neuroimaging studies have …
Using the MATRICS to guide development of a preclinical cognitive test battery for research in schizophrenia
Cognitive deficits in schizophrenia are among the core symptoms of the disease, correlate
with functional outcome, and are not well treated with current antipsychotic therapies. In …
with functional outcome, and are not well treated with current antipsychotic therapies. In …
[HTML][HTML] Catechol-O-methyltransferase val158met polymorphism predicts placebo effect in irritable bowel syndrome
Identifying patients who are potential placebo responders has major implications for clinical
practice and trial design. Catechol-O-methyltransferase (COMT), an important enzyme in …
practice and trial design. Catechol-O-methyltransferase (COMT), an important enzyme in …
Prepulse inhibition and genetic mouse models of schizophrenia
SB Powell, X Zhou, MA Geyer - Behavioural brain research, 2009 - Elsevier
Mutant mouse models related to schizophrenia have been based primarily on the
pathophysiology of schizophrenia, the known effects of antipsychotic drugs, and candidate …
pathophysiology of schizophrenia, the known effects of antipsychotic drugs, and candidate …
Effects of COMT polymorphisms on brain function and behavior in health and disease
AV Witte, A Flöel - Brain research bulletin, 2012 - Elsevier
The catechol-O-methyltransferase (COMT) gene has attracted strong neuroscientific interest
due to its implication in dopaminergic neurotransmission. One of its most widely studied …
due to its implication in dopaminergic neurotransmission. One of its most widely studied …
[HTML][HTML] COMT Val158Met genotype determines the direction of cognitive effects produced by catechol-O-methyltransferase inhibition
SM Farrell, EM Tunbridge, S Braeutigam… - Biological psychiatry, 2012 - Elsevier
BACKGROUND: Catechol-O-methyltransferase (COMT) metabolizes dopamine. The COMT
Val158Met polymorphism influences its activity, and multiple neural correlates of this …
Val158Met polymorphism influences its activity, and multiple neural correlates of this …
Influence of the COMT genotype on working memory and brain activity changes during development
BACKGROUND: The Valine158Methionine (Val158Met) polymorphism of the COMT gene
leads to lower enzymatic activity and higher dopamine availability in Met carriers. The Met …
leads to lower enzymatic activity and higher dopamine availability in Met carriers. The Met …