Adult stem cells are important for mammalian tissues, where they act as a cell reserve that
supports normal tissue turnover and can mount a regenerative response following acute …

Skeletal muscle possesses a remarkable ability to adapt to various physiologic conditions.
AMPK is a sensor of intracellular energy status that maintains energy stores by fine-tuning …

Metabolism has been studied mainly in cultured cells or at the level of whole tissues or
whole organisms in vivo. Consequently, our understanding of metabolic heterogeneity …

AMPK (5'-adenosine monophosphate-activated protein kinase) is heavily involved in
skeletal muscle metabolic control through its regulation of many downstream targets …

Sarcopenia and myopathies cause progressive muscle weakness and degeneration, which
are closely associated with fat infiltration and fibrosis in muscle. Recently, experimental …

Although there are several reviews that report the interrelationship between sarcopenia and
obesity and insulin resistance, the relation between sarcopenia and the other signs that …

While metabolism was initially thought to play a passive role in cell biology by generating
ATP to meet bioenergetic demands, recent studies have identified critical roles for …

Adult stem cells, particularly those resident in tissues with little turnover, are largely
quiescent and only activate in response to regenerative demands, while embryonic stem …

Skeletal muscle possesses a remarkable plasticity and responds to environmental and
physiological challenges by changing its phenotype in terms of size, composition, and …

Regeneration of skeletal muscles is limited in cases of volumetric muscle loss and muscle
degenerative diseases. Therefore, there is a critical need for develo** strategies that …