Polyunsaturated fatty acids (PUFAs) are structural components of membrane phospholipids,
and influence cellular function via effects on membrane properties, and also by acting as a …

A wide spectrum of metabolites (mainly, the three major nutrients and their derivatives) can
be sensed by specific sensors, then trigger a series of signal transduction pathways and …

Cardiovascular diseases are described as the leading cause of morbidity and mortality in
modern societies. Therefore, the importance of cardiovascular diseases prevention is widely …

In the context of OA disease, NF-κB transcription factors can be triggered by a host of stress-
related stimuli including pro-inflammatory cytokines, excessive mechanical stress and ECM …

The important role of diet in cardiometabolic health is generally well recognised; for mental
health, it is not so well understood. However, lifestyle risk factors for poor physical health are …

Oxidative stress represents a situation where there is an imbalance between the reactive
oxygen species (ROS) and the availability and the activity of antioxidants. This balance is …

The cyclopentenone unit is a very powerful synthon for the synthesis of a variety of bioactive
target molecules. This is due to the broad diversity of chemical modifications available for …

Lipid peroxidation is a complex process involving the interaction of oxygen-derived free
radicals with polyunsaturated fatty acids, resulting in a variety of highly reactive electrophilic …

The amyloid hypothesis (AH) of Alzheimer's disease (AD) posits that the fundamental cause
of AD is the accumulation of the peptide amyloid beta (Aβ) in the brain. This hypothesis has …

Oxygen has a central role in the evolution of complex life on Earth mainly because of the
biochemical symmetry of oxygenic photosynthesis and aerobic respiration that can maintain …