Transcription is regulated and mediated by multiprotein complexes in a chromatin context.
Transcription causes changes in DNA topology which is modulated by DNA …

Collaboration of transcription factors (TFs) and their recognition motifs in DNA is the result of
coevolution and forms the basis of gene regulation. However, the way how these short …

Mammalian promoters consist of multifarious elements, which make them unique and
support the selection of the proper transcript variants required under diverse conditions in …

All-trans retinoic acid (ATRA) is a derivative of vitamin A that has many important biological
functions, including the modulation of immune responses. ATRA actions are mediated …

Work over the past 30 years has shown that lipid-activated nuclear receptors form a bridge
between metabolism and immunity integrating metabolic and inflammatory signaling in …

The liver is a fundamental regulator of metabolic physiology. The hepatocyte requires
signaling mechanisms to sense and respond to fluctuations in nutrient availability. This is …