What we talk about when we talk about fat
There has been an upsurge of interest in the adipocyte coincident with the onset of the
obesity epidemic and the realization that adipose tissue plays a major role in the regulation …
obesity epidemic and the realization that adipose tissue plays a major role in the regulation …
The role of hypoxia-inducible factors in metabolic diseases
FJ Gonzalez, C ** type 2 diabetes. We investigated whether DNA methylation is …
Hypoxia-inducible factors and the regulation of lipid metabolism
Oxygen deprivation or hypoxia characterizes a number of serious pathological conditions
and elicits a number of adaptive changes that are mainly mediated at the transcriptional …
and elicits a number of adaptive changes that are mainly mediated at the transcriptional …
[HTML][HTML] Obesity and cancer: the role of adipose tissue and adipo-cytokines-induced chronic inflammation
Adipose tissue in addition to its ability to keep lipids is now recognized as a real organ with
both metabolic and endocrine functions. Recent studies demonstrated that in obese animals …
both metabolic and endocrine functions. Recent studies demonstrated that in obese animals …
Tumor-associated fibrosis as a regulator of tumor immunity and response to immunotherapy
Tumor-associated fibrosis is characterized by unchecked pro-fibrotic and pro-inflammatory
signaling. The components of fibrosis including significant numbers of cancer-associated …
signaling. The components of fibrosis including significant numbers of cancer-associated …
[HTML][HTML] Homocysteine causes vascular endothelial dysfunction by disrupting endoplasmic reticulum redox homeostasis
X Wu, L Zhang, Y Miao, J Yang, X Wang, C Wang… - Redox biology, 2019 - Elsevier
Endothelial dysfunction induced by hyperhomocysteinemia (HHcy) plays a critical role in
vascular pathology. However, little is known about the role of endoplasmic reticulum (ER) …
vascular pathology. However, little is known about the role of endoplasmic reticulum (ER) …
HIF-1α inhibitor PX-478 preserves pancreatic β cell function in diabetes
E Ilegems, G Bryzgalova, J Correia… - Science translational …, 2022 - science.org
During progression of type 2 diabetes, pancreatic β cells are subjected to sustained
metabolic overload. We postulated that this state mediates a hypoxic phenotype driven by …
metabolic overload. We postulated that this state mediates a hypoxic phenotype driven by …