A brief history of organoids

C Corrò, L Novellasdemunt… - American Journal of …, 2020 - journals.physiology.org
In vitro cell cultures are crucial research tools for modeling human development and
diseases. Although the conventional monolayer cell cultures have been widely used in the …

[HTML][HTML] AI-enabled organoids: construction, analysis, and application

L Bai, Y Wu, G Li, W Zhang, H Zhang, J Su - Bioactive Materials, 2024 - Elsevier
Organoids, miniature and simplified in vitro model systems that mimic the structure and
function of organs, have attracted considerable interest due to their promising applications in …

Causes and consequences of snake venom variation

NR Casewell, TNW Jackson, AH Laustsen… - Trends in …, 2020 - cell.com
Snake venoms are mixtures of toxins that vary extensively between and within snake
species. This variability has serious consequences for the management of the world's 1.8 …

Somatic cell-derived organoids as prototypes of human epithelial tissues and diseases

M Fujii, T Sato - Nature Materials, 2021 - nature.com
Recent progress in our understanding of the regulation of epithelial tissue stem cells has
allowed us to exploit their abilities and instruct them to self-organize into tissue-mimicking …

[HTML][HTML] Organoids to model liver disease

S Nuciforo, MH Heim - JHEP Reports, 2021 - Elsevier
The organoid model represents a major breakthrough in cell biology that has revolutionised
biomedical research. Organoids are 3D physiological in vitro structures that recapitulate …

Global Literature Analysis of Organoid and Organ‐on‐Chip Research

J Shoji, RP Davis, CL Mummery… - Advanced healthcare …, 2024 - Wiley Online Library
Organoids and cells in organ‐on‐chip platforms replicate higher‐level anatomical,
physiological, or pathological states of tissues and organs. These technologies are widely …

Hallmarks of stemness in mammalian tissues

J Beumer, H Clevers - Cell Stem Cell, 2024 - cell.com
All adult tissues experience wear and tear. Most tissues can compensate for cell loss
through the activity of resident stem cells. Although the cellular maintenance strategies vary …

[HTML][HTML] Future regenerative medicine developments and their therapeutic applications

AE Altyar, A El-Sayed, A Abdeen, M Piscopo… - Biomedicine & …, 2023 - Elsevier
Although the currently available pharmacological assays can cure most pathological
disorders, they have limited therapeutic value in relieving certain disorders like myocardial …

Culture and analysis of kidney tubuloids and perfused tubuloid cells-on-a-chip

L Gijzen, FA Yousef Yengej, F Schutgens… - Nature protocols, 2021 - nature.com
Advanced in vitro kidney models are of great importance to the study of renal physiology and
disease. Kidney tubuloids can be established from primary cells derived from adult kidney …

Cancer research using organoid technology

K Kretzschmar - Journal of Molecular Medicine, 2021 - Springer
Organoid technology has rapidly transformed basic biomedical research and contributed to
significant discoveries in the last decade. With the application of protocols to generate …