Clinical Diagnostics of Bacterial Infections and Their Resistance to Antibiotics—Current State and Whole Genome Sequencing Implementation Perspectives
Antimicrobial resistance (AMR), defined as the ability of microorganisms to withstand
antimicrobial treatment, is responsible for millions of deaths annually. The rapid spread of …
antimicrobial treatment, is responsible for millions of deaths annually. The rapid spread of …
The notable achievements and the prospects of bacterial pathogen genomics
Throughout the entirety of human history, bacterial pathogens have played an important role
and even shaped the fate of civilizations. The application of genomics within the last 27 …
and even shaped the fate of civilizations. The application of genomics within the last 27 …
A rapid bacterial pathogen and antimicrobial resistance diagnosis workflow using Oxford nanopore adaptive sequencing method
H Cheng, Y Sun, Q Yang, M Deng, Z Yu… - Briefings in …, 2022 - academic.oup.com
Metagenomic sequencing analysis (mNGS) has been implemented as an alternative
approach for pathogen diagnosis in recent years, which is independent of cultivation and is …
approach for pathogen diagnosis in recent years, which is independent of cultivation and is …
An integrated method for targeted Oxford Nanopore sequencing and automated bioinformatics for the simultaneous detection of bacteria, fungi, and ARG
S Kuruwa, A Zade, S Shah, R Moidu… - Journal of Applied …, 2024 - academic.oup.com
Aims The use of metagenomics for pathogen identification in clinical practice has been
limited. Here we describe a workflow to encourage the clinical utility and potential of NGS for …
limited. Here we describe a workflow to encourage the clinical utility and potential of NGS for …
The application of targeted nanopore sequencing for the identification of pathogens and resistance genes in lower respiratory tract infections
H Zhang, M Wang, X Han, T Wang, Y Lei… - Frontiers in …, 2022 - frontiersin.org
Objectives Lower respiratory tract infections (LRTIs) are one of the causes of mortality
among infectious diseases. Microbial cultures commonly used in clinical practice are time …
among infectious diseases. Microbial cultures commonly used in clinical practice are time …
Hospital antimicrobial stewardship: profiling the oral microbiome after exposure to COVID-19 and antibiotics
P Buendia, K Fernandez, C Raley… - Frontiers in …, 2024 - frontiersin.org
Introduction During the COVID-19 Delta variant surge, the CLAIRE cross-sectional study
sampled saliva from 120 hospitalized patients, 116 of whom had a positive COVID-19 PCR …
sampled saliva from 120 hospitalized patients, 116 of whom had a positive COVID-19 PCR …
Optimizing nanopore sequencing for rapid detection of microbial species and antimicrobial resistance in patients at risk of surgical site infections
Surgical site infections (SSI) are a significant burden to patients and health care systems.
We evaluated the use of Nanopore sequencing (NS) to rapidly detect microbial species and …
We evaluated the use of Nanopore sequencing (NS) to rapidly detect microbial species and …
Rapid detection of multidrug resistance in tuberculosis using nanopore-based targeted next-generation sequencing: a multicenter, double-blind study
A Liu, S Liu, K Lv, Q Zhu, J Wen, J Li, C Liang… - Frontiers in …, 2024 - frontiersin.org
Background Resistance to anti-tuberculous drugs is a major challenge in the treatment of
tuberculosis (TB). We aimed to evaluate the clinical availability of nanopore-based targeted …
tuberculosis (TB). We aimed to evaluate the clinical availability of nanopore-based targeted …
An ultra-sensitive bacterial pathogen and antimicrobial resistance diagnosis workflow using Oxford Nanopore adaptive sampling sequencing method
H Cheng, Y Sun, Q Yang, M Deng, Z Yu, L Liu, L Yang… - medRxiv, 2022 - medrxiv.org
Metagenomic sequencing analysis has been implemented as an alternative approach for
pathogen diagnosis in recent years, which is independent on cultivation and able to identify …
pathogen diagnosis in recent years, which is independent on cultivation and able to identify …
Unlocking the Power of Nanopores: Recent Advances in Biosensing Applications and Analog Front-End
M Liu, J Li, CS Tan - Biosensors, 2023 - mdpi.com
The biomedical field has always fostered innovation and the development of various new
technologies. Beginning in the last century, demand for picoampere-level current detection …
technologies. Beginning in the last century, demand for picoampere-level current detection …