Abstract Background The Wnt signaling pathway is a complex network of protein interactions
that functions most commonly in embryonic development and cancer, but is also involved in …

Janus kinase/signal transduction and transcription activation (JAK/STAT) pathways were
originally thought to be intracellular signaling pathways that mediate cytokine signals in …

Oxidative stress and AKT serine-threonine kinase (AKT) are responsible for regulating
several cell functions of cancer cells. Several natural products modulate both oxidative …

Immunogenic cell death (ICD) is a regulated cell death (RCD) pathway. In response to
physical and chemical signals, tumor cells activate specific signaling pathways that stimulate …

Abstract Cyclin-dependent kinase 12 (CDK12) is a member of the CDK family of proteins
(CDK) and is critical for cancer development. Years of study into CDK12 have generated …

Cardiac glycosides (CGs) have a long history of treating cardiac diseases. However, recent
reports have suggested that CGs also possess anticancer and antiviral activities. The …

Abstract Changes in lifestyle such as physical activity and eating habits have been one of
the main reasons for development of various diseases in modern world, especially cancer …

Cardiac glycosides are natural sterols and constitute a group of secondary metabolites
isolated from plants and animals. These cardiotonic agents are well recognized and …

Schizophrenia (SCZ) is a sophisticated neurodevelopmental disorder, but the mechanisms
remain ambiguous. Thus, we analyzed the transcriptomic datasets to investigate the …

Background: KIFC3, belongs to kinesin superfamily proteins (KIFs), is well known for its role
in intracellular cargo movement. KIFC3 has been identified as a docetaxel resistance gene …