Lysosomes are ubiquitous membrane-bound intracellular organelles with an acidic interior.
They are central for degradation and recycling of macromolecules delivered by endocytosis …

Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Macroautophagy/autophagy is a conserved transport pathway where targeted structures are
sequestered by phagophores, which mature into autophagosomes, and then delivered into …

Stereochemistry can alter small-molecule pharmacokinetics, safety and efficacy. However, it
is unclear whether the stereochemistry of a single compound within a multicomponent …

INTRODUCTION Parkinson's disease (PD) is the second most common neurodegenerative
disorder and leads to slowness of movement, tremor, rigidity, and, in the later stages of PD …

Intracellular membrane traffic defines a complex network of pathways that connects many of
the membrane-bound organelles of eukaryotic cells. Although each pathway is governed by …

At the onset of metazoan cell division the nuclear envelope breaks down to enable capture
of chromosomes by the microtubule-containing spindle apparatus. During anaphase, when …

Deregulation of Akt/protein kinase B (PKB) is implicated in the pathogenesis of cancer and
diabetes. Akt/PKB activation requires the phosphorylation of Thr308 in the activation loop by …

Cellular organelles in the exocytic and endocytic pathways have a distinctive spatial
distribution and communicate through an elaborate system of vesiculo-tubular transport …

Cells use noncanonical autophagy, also called conjugation of ATG8 to single membranes
(CASM), to label damaged intracellular compartments with ubiquitin‐like ATG8 family …