Objective To synthesise the evidence on the effects of physical activity on symptoms of
depression, anxiety and psychological distress in adult populations. Design Umbrella …

Major depressive disorder (MDD) is characterized by persistent depressed mood, loss of
interest or pleasure in previously enjoyable activities, recurrent thoughts of death, and …

Depression is common, costly, debilitating, and associated with increased risk of suicide. It is
one of the leading global public health problems. Although existing available …

Objective To estimate the efficacy of exercise on depressive symptoms compared with non-
active control groups and to determine the moderating effects of exercise on depression and …

Executive summary “Depression is a disorder of mood, so mysteriously painful and elusive
in the way it becomes known to the self—to the mediating intellect—as to verge close to …

Introduction Major depression is a common and potentially lethal condition. Early data
suggest that the population-level burden of depression has been exacerbated by the COVID …

Background Behavioural, cognitive, and pharmacological interventions can all be effective
for insomnia. However, because of inadequate resources, medications are more frequently …

Mental disorders represent a worldwide public health concern. Psychotherapies and
pharmacotherapies are recommended as first line treatments. However, evidence has …

Depressive disorders are among the leading causes of global disease burden, but there has
been limited progress in understanding the causes of and treatments for these disorders. In …

Background Psilocybin may have antidepressant properties, but direct comparisons
between psilocybin and established treatments for depression are lacking. Methods In a …