Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials
Y Cheng, C He, M Wang, X Ma, F Mo, S Yang… - Signal transduction and …, 2019 - nature.com
Epigenetic alternations concern heritable yet reversible changes in histone or DNA
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …
[HTML][HTML] Histone acetyltransferases CBP/p300 in tumorigenesis and CBP/p300 inhibitors as promising novel anticancer agents
Q Chen, B Yang, X Liu, XD Zhang, L Zhang, T Liu - Theranostics, 2022 - ncbi.nlm.nih.gov
The histone acetyltransferases CBP and p300, often referred to as CBP/p300 due to their
sequence homology and functional overlap and co-operation, are emerging as critical …
sequence homology and functional overlap and co-operation, are emerging as critical …
Protein lysine acetylation by p300/CBP
Since their discovery in the 1980s and 1990s, the human protein lysine acetyltransferase
encoded by the paralogous p300 and CBP genes has received much interest. p300/CBP …
encoded by the paralogous p300 and CBP genes has received much interest. p300/CBP …
Curcumin, a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone …
Acetylation of histones and non-histone proteins is an important post-translational
modification involved in the regulation of gene expression in eukaryotes and all viral DNA …
modification involved in the regulation of gene expression in eukaryotes and all viral DNA …
Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor
EM Bowers, G Yan, C Mukherjee, A Orry, L Wang… - Chemistry & biology, 2010 - cell.com
The histone acetyltransferase (HAT) p300/CBP is a transcriptional coactivator implicated in
many gene regulatory pathways and protein acetylation events. Although p300 inhibitors …
many gene regulatory pathways and protein acetylation events. Although p300 inhibitors …
Acetylation of non-histone proteins modulates cellular signalling at multiple levels
This review focuses on the posttranslational acetylation of non-histone proteins, which
determines vital regulatory processes. The recruitment of histone acetyltransferases and …
determines vital regulatory processes. The recruitment of histone acetyltransferases and …
Bromodomain inhibitors and cancer therapy: From structures to applications
M Pérez-Salvia, M Esteller - Epigenetics, 2017 - Taylor & Francis
Aberrations in the epigenetic landscape are a hallmark of cancer. Alterations in enzymes
that are “writers,”“erasers,” or “readers” of histone modification marks are common …
that are “writers,”“erasers,” or “readers” of histone modification marks are common …
Cancer chemoprevention by dietary polyphenols: promising role for epigenetics
Epigenetics refers to heritable changes that are not encoded in the DNA sequence itself, but
play an important role in the control of gene expression. In mammals, epigenetic …
play an important role in the control of gene expression. In mammals, epigenetic …
Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression
Histone acetylation is a diagnostic feature of transcriptionally active genes. The proper
recruitment and function of histone acetyltransferases (HATs) and deacetylases (HDACs) …
recruitment and function of histone acetyltransferases (HATs) and deacetylases (HDACs) …
Use of epigenetic drugs in disease: an overview
Epigenetic changes such as DNA methylation and histone methylation and acetylation alter
gene expression at the level of transcription by upregulating, downregulating, or silencing …
gene expression at the level of transcription by upregulating, downregulating, or silencing …