Genetic susceptibility to type 2 diabetes and obesity: from genome-wide association studies to rare variants and beyond
During the past 7 years, genome-wide association studies have shed light on the
contribution of common genomic variants to the genetic architecture of type 2 diabetes …
contribution of common genomic variants to the genetic architecture of type 2 diabetes …
Type 2 diabetes: genetic data sharing to advance complex disease research
As with other complex diseases, unbiased association studies followed by physiological and
experimental characterization have for years formed a paradigm for identifying genes or …
experimental characterization have for years formed a paradigm for identifying genes or …
The genetic architecture of type 2 diabetes
The genetic architecture of common traits, including the number, frequency, and effect sizes
of inherited variants that contribute to individual risk, has been long debated. Genome-wide …
of inherited variants that contribute to individual risk, has been long debated. Genome-wide …
A combined polygenic score of 21,293 rare and 22 common variants improves diabetes diagnosis based on hemoglobin A1C levels
Polygenic scores (PGSs) combine the effects of common genetic variants, to predict risk or
treatment strategies for complex diseases,,,–. Adding rare variation to PGSs has largely …
treatment strategies for complex diseases,,,–. Adding rare variation to PGSs has largely …
A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes
The Greenlandic population, a small and historically isolated founder population comprising
about 57,000 inhabitants, has experienced a dramatic increase in type 2 diabetes (T2D) …
about 57,000 inhabitants, has experienced a dramatic increase in type 2 diabetes (T2D) …
Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls
Protein-coding genetic variants that strongly affect disease risk can yield relevant clues to
disease pathogenesis. Here we report exome-sequencing analyses of 20,791 individuals …
disease pathogenesis. Here we report exome-sequencing analyses of 20,791 individuals …
[HTML][HTML] Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis
Thermogenic adipocytes possess a therapeutically appealing, energy-expending capacity,
which is canonically cold-induced by ligand-dependent activation of β-adrenergic G protein …
which is canonically cold-induced by ligand-dependent activation of β-adrenergic G protein …
Association of a low-frequency variant in HNF1A with type 2 diabetes in a Latino population
Importance Latino populations have one of the highest prevalences of type 2 diabetes
worldwide. Objectives To investigate the association between rare protein-coding genetic …
worldwide. Objectives To investigate the association between rare protein-coding genetic …
Inference of the distribution of selection coefficients for new nonsynonymous mutations using large samples
The distribution of fitness effects (DFE) has considerable importance in population genetics.
To date, estimates of the DFE come from studies using a small number of individuals. Thus …
To date, estimates of the DFE come from studies using a small number of individuals. Thus …
Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes
We have identified a variant in ADCY3 (encoding adenylate cyclase 3) associated with
markedly increased risk of obesity and type 2 diabetes in the Greenlandic population. The …
markedly increased risk of obesity and type 2 diabetes in the Greenlandic population. The …