Molecular mechanism of Nramp-family transition metal transport
The Natural resistance-associated macrophage protein (Nramp) family of transition metal
transporters enables uptake and trafficking of essential micronutrients that all organisms …
transporters enables uptake and trafficking of essential micronutrients that all organisms …
When too much ATP is bad for protein synthesis
Adenosine triphosphate (ATP) is the energy currency of living cells. Even though ATP
powers virtually all energy-dependent activities, most cellular ATP is utilized in protein …
powers virtually all energy-dependent activities, most cellular ATP is utilized in protein …
Host resistance factor SLC11A1 restricts Salmonella growth through magnesium deprivation
O Cunrath, D Bumann - Science, 2019 - science.org
The pleiotropic host resistance factor SLC11A1 (NRAMP1) defends against diverse
intracellular pathogens in mammals by yet-unknown mechanisms. We compared …
intracellular pathogens in mammals by yet-unknown mechanisms. We compared …
Cellular Adaptations to Cytoplasmic Mg2+ Limitation
EA Groisman, C Chan - Annual review of microbiology, 2021 - annualreviews.org
Mg2+ is the most abundant divalent cation in living cells. It is essential for charge
neutralization, macromolecule stabilization, and the assembly and activity of ribosomes and …
neutralization, macromolecule stabilization, and the assembly and activity of ribosomes and …
Conserved methionine dictates substrate preference in Nramp-family divalent metal transporters
Natural resistance-associated macrophage protein (Nramp) family transporters catalyze
uptake of essential divalent transition metals like iron and manganese. To discriminate …
uptake of essential divalent transition metals like iron and manganese. To discriminate …
Molecular logic of the Zur-regulated zinc deprivation response in Bacillus subtilis
Bacteria respond dynamically to the changes in zinc availability. Repression by the Bacillus
subtilis transcription factor Zur requires Zn (II), which binds with negative cooperativity to two …
subtilis transcription factor Zur requires Zn (II), which binds with negative cooperativity to two …
Bacillus subtilis MntR coordinates the transcriptional regulation of manganese uptake and efflux systems
X Huang, JH Shin, A Pinochet‐Barros… - Molecular …, 2017 - Wiley Online Library
Summary The Bacillus subtilis MntR metalloregulatory protein senses manganese, an
essential element required for central metabolism, oxidative stress resistance and …
essential element required for central metabolism, oxidative stress resistance and …
Nuclear envelope, chromatin organizers, histones, and DNA: The many achilles heels exploited across cancers
AK Balaji, S Saha, S Deshpande, D Poola… - Frontiers in Cell and …, 2022 - frontiersin.org
In eukaryotic cells, the genome is organized in the form of chromatin composed of DNA and
histones that organize and regulate gene expression. The dysregulation of chromatin …
histones that organize and regulate gene expression. The dysregulation of chromatin …
Bypassing iron storage in endodermal vacuoles rescues the iron mobilization defect in the natural resistance associated-macrophage protein3natural resistance …
V Mary, M Schnell Ramos, C Gillet, AL Socha… - Plant …, 2015 - academic.oup.com
To improve seed iron (Fe) content and bioavailability, it is crucial to decipher the
mechanisms that control Fe storage during seed development. In Arabidopsis (Arabidopsis …
mechanisms that control Fe storage during seed development. In Arabidopsis (Arabidopsis …
Acinetobacter baumannii coordinates urea metabolism with metal import to resist host-mediated metal limitation
During infection, bacterial pathogens must adapt to a nutrient metal-limited environment that
is imposed by the host. The innate immune protein calprotectin inhibits bacterial growth in …
is imposed by the host. The innate immune protein calprotectin inhibits bacterial growth in …