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Strategies for map** and cloning quantitative trait genes in rodents
Over the past 15 years, more than 2,000 quantitative trait loci (QTLs) have been identified in
crosses between inbred strains of mice and rats, but less than 1% have been characterized …
crosses between inbred strains of mice and rats, but less than 1% have been characterized …
Maintenance of ancestral complexity and non-metazoan genes in two basal cnidarians
U Technau, S Rudd, P Maxwell, PMK Gordon… - TRENDS in …, 2005 - cell.com
Cnidarians are among the simplest extant animals; however EST analyses reveal that they
have a remarkably high level of genetic complexity. In this article, we show that the full …
have a remarkably high level of genetic complexity. In this article, we show that the full …
Subspecific origin and haplotype diversity in the laboratory mouse
Here we provide a genome-wide, high-resolution map of the phylogenetic origin of the
genome of most extant laboratory mouse inbred strains. Our analysis is based on the …
genome of most extant laboratory mouse inbred strains. Our analysis is based on the …
A sequence-based variation map of 8.27 million SNPs in inbred mouse strains
A dense map of genetic variation in the laboratory mouse genome will provide insights into
the evolutionary history of the species and lead to an improved understanding of the …
the evolutionary history of the species and lead to an improved understanding of the …
On the subspecific origin of the laboratory mouse
H Yang, TA Bell, GA Churchill… - Nature …, 2007 - nature.com
The genome of the laboratory mouse is thought to be a mosaic of regions with distinct
subspecific origins. We have developed a high-resolution map of the origin of the laboratory …
subspecific origins. We have developed a high-resolution map of the origin of the laboratory …
The genetic landscape of type 2 diabetes in mice
Inbred mouse strains provide genetic diversity comparable to that of the human population.
Like humans, mice have a wide range of diabetes-related phenotypes. The inbred mouse …
Like humans, mice have a wide range of diabetes-related phenotypes. The inbred mouse …
Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice
B Yalcin, SAG Willis-Owen, J Fullerton, A Meesaq… - Nature …, 2004 - nature.com
Here we present a strategy to determine the genetic basis of variance in complex
phenotypes that arise from natural, as opposed to induced, genetic variation in mice. We …
phenotypes that arise from natural, as opposed to induced, genetic variation in mice. We …
Genetic variation in the zebrafish
V Guryev, MJ Koudijs, E Berezikov… - Genome …, 2006 - genome.cshlp.org
Although zebrafish was introduced as a laboratory model organism several decades ago
and now serves as a primary model for developmental biology, there is only limited data on …
and now serves as a primary model for developmental biology, there is only limited data on …
A high-resolution map of segmental DNA copy number variation in the mouse genome
TA Graubert, P Cahan, D Edwin, RR Selzer… - PLoS …, 2007 - journals.plos.org
Submicroscopic (less than 2 Mb) segmental DNA copy number changes are a recently
recognized source of genetic variability between individuals. The biological consequences …
recognized source of genetic variability between individuals. The biological consequences …
Collaborative Cross mice and their power to map host susceptibility to Aspergillus fumigatus infection
The Collaborative Cross (CC) is a genetic reference panel of recombinant inbred lines of
mice, designed for the dissection of complex traits and gene networks. Each line is …
mice, designed for the dissection of complex traits and gene networks. Each line is …