Treating bacterial infections with bacteriophage-based enzybiotics: in vitro, in vivo and clinical application
Over the past few decades, we have witnessed a surge around the world in the emergence
of antibiotic-resistant bacteria. This global health threat arose mainly due to the overuse and …
of antibiotic-resistant bacteria. This global health threat arose mainly due to the overuse and …
Genetically engineered phages: a review of advances over the last decade
Soon after their discovery in the early 20th century, bacteriophages were recognized to have
great potential as antimicrobial agents, a potential that has yet to be fully realized. The …
great potential as antimicrobial agents, a potential that has yet to be fully realized. The …
Engineered endolysin-based “Artilysins” to combat multidrug-resistant gram-negative pathogens
Y Briers, M Walmagh, V Van Puyenbroeck… - MBio, 2014 - Am Soc Microbiol
The global threat to public health posed by emerging multidrug-resistant bacteria in the past
few years necessitates the development of novel approaches to combat bacterial infections …
few years necessitates the development of novel approaches to combat bacterial infections …
Drivers and consequences of bacteriophage host range
Bacteriophages are obligate parasites of bacteria characterized by the breadth of hosts that
they can infect. This “host range” depends on the genotypes and morphologies of the phage …
they can infect. This “host range” depends on the genotypes and morphologies of the phage …
Bacteriophage-mediated control of biofilm: a promising new dawn for the future
C Chang, X Yu, W Guo, C Guo, X Guo, Q Li… - Frontiers in …, 2022 - frontiersin.org
Biofilms are complex microbial microcolonies consisting of planktonic and dormant bacteria
bound to a surface. The bacterial cells within the biofilm are embedded within the …
bound to a surface. The bacterial cells within the biofilm are embedded within the …
Learning from bacteriophages-advantages and limitations of phage and phage-encoded protein applications
The emergence of bacteria resistance to most of the currently available antibiotics has
become a critical therapeutic problem. The bacteria causing both hospital and community …
become a critical therapeutic problem. The bacteria causing both hospital and community …
Finding alternatives to antibiotics
The spread of antibiotic‐resistant pathogens requires new treatments. As the rate of
development of new antibiotics has severely declined, alternatives to antibiotics must be …
development of new antibiotics has severely declined, alternatives to antibiotics must be …
Viruses versus bacteria—novel approaches to phage therapy as a tool against multidrug-resistant pathogens
TM Viertel, K Ritter, HP Horz - Journal of Antimicrobial …, 2014 - academic.oup.com
Bacteriophage therapy (the application of phages to treat bacterial infections) has a tradition
dating back almost a century, but interest in phage therapy slowed down in the West when …
dating back almost a century, but interest in phage therapy slowed down in the West when …
Antimicrobial bacteriophage-derived proteins and therapeutic applications
DR Roach, DM Donovan - Bacteriophage, 2015 - Taylor & Francis
Antibiotics have the remarkable power to control bacterial infections. Unfortunately,
widespread use, whether regarded as prudent or not, has favored the emergence and …
widespread use, whether regarded as prudent or not, has favored the emergence and …
Endolysins as emerging alternative therapeutic agents to counter drug-resistant infections
Endolysins are the lytic products of bacteriophages which play a specific role in the release
of phage progeny by degrading the peptidoglycan of the host bacterium. In the light of …
of phage progeny by degrading the peptidoglycan of the host bacterium. In the light of …