According to the widely accepted" three Es" model, the host immune system eliminates
malignant cell precursors and contains microscopic neoplasms in a dynamic equilibrium …

Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of fatty
deposits in the inner walls of vessels. These plaques restrict blood flow and lead to …

Nonalcoholic fatty liver disease (NAFLD) and alcohol-related liver disease (ALD) are the
leading causes of chronic liver disease worldwide. NAFLD and ALD share …

Tumor hypoxia resulting from abnormal and dysfunctional tumor vascular network poses a
substantial obstacle to immunotherapy. In fact, hypoxia creates an immunosuppressive …

The ability of mammals to mount adaptive immune responses culminating with the
establishment of immunological memory is predicated on the ability of the mature T cell …

Most metastatic cancers remain incurable due to the emergence of apoptosis-resistant
clones, fuelled by intratumour heterogeneity and tumour evolution. To improve treatment …

Colorectal cancer is a major public health concern, with increasing incidence and mortality
rates worldwide. Environmental factors, including exposure to toxic metals, such as lead …

Ferroptosis is an iron-and reactive oxygen species (ROS)-dependent form of regulated cell
death, that has been implicated in Alzheimer's disease and Parkinson's disease. Inhibition of …

Type I interferon (IFN) is a class of proinflammatory cytokines with a dual role on malignant
transformation, tumor progression, and response to therapy. On the one hand, robust, acute …

Ferroptosis has attracted attention throughout the last decade because of its tremendous
clinical importance. Here, we review the rapidly growing body of literature on how inhibition …