The generation of organismal form—morphogenesis—arises from forces produced at the
cellular level. In animal cells, much of this force is produced by the actin cytoskeleton. Here …

D'Arcy Thompson was a proponent of applying mathematical and physical principles to
biological systems, an approach that is becoming increasingly common in developmental …

The human embryo breaks symmetry to form the anterior-posterior axis of the body. As the
embryo elongates along this axis, progenitors in the tail bud give rise to tissues that …

Transformation from morula to blastocyst is a defining event of preimplantation embryo
development. During this transition, the embryo must establish a paracellular permeability …

Although understanding how soluble cues direct cellular processes revolutionised the study
of cell biology in the second half of the 20th century, over the last two decades, new insights …

The generation of the components that make up the embryonic body axis, such as the spinal
cord and vertebral column, takes place in an anterior-to-posterior (head-to-tail) direction …

The complexity of morphogenesis poses a fundamental challenge to understanding the
mechanisms governing the formation of biological patterns and structures. Over the past …

The development of the vertebrate spinal cord involves the formation of the neural tube and
the generation of multiple distinct cell types. The process starts during gastrulation …

Organ morphogenesis is multifaceted, multiscale, and fundamentally a robust process.
Despite the complex and dynamic nature of embryonic development, organs are built with …

A critical juncture in early development is the partitioning of cells that will adopt different
fates into three germ layers: the ectoderm, the mesoderm, and the endoderm. This step is …