The E-cadherin and N-cadherin switch in epithelial-to-mesenchymal transition: signaling, therapeutic implications, and challenges
Epithelial-to-Mesenchymal Transition (EMT) has been shown to be crucial in tumorigenesis
where the EMT program enhances metastasis, chemoresistance and tumor stemness. Due …
where the EMT program enhances metastasis, chemoresistance and tumor stemness. Due …
[HTML][HTML] 5-Fluorouracil (5-FU) resistance and the new strategy to enhance the sensitivity against cancer: Implication of DNA repair inhibition
Fluorouracil (5-FU) has been an important anti-cancer drug to date. With an increase in the
knowledge of its mechanism of action, various treatment modalities have been developed …
knowledge of its mechanism of action, various treatment modalities have been developed …
Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds
HL Ang, CD Mohan, MK Shanmugam… - Medicinal research …, 2023 - Wiley Online Library
Epithelial‐mesenchymal transition (EMT) is a complex process with a primordial role in
cellular transformation whereby an epithelial cell transforms and acquires a mesenchymal …
cellular transformation whereby an epithelial cell transforms and acquires a mesenchymal …
Targeting epithelial–mesenchymal transition (EMT) to overcome drug resistance in cancer
Epithelial–mesenchymal transition (EMT) is known to play an important role in cancer
progression, metastasis and drug resistance. Although there are controversies surrounding …
progression, metastasis and drug resistance. Although there are controversies surrounding …
Epigenetic alterations in colorectal cancer: emerging biomarkers
Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. One of the
fundamental processes driving the initiation and progression of CRC is the accumulation of …
fundamental processes driving the initiation and progression of CRC is the accumulation of …
The role of polyphenols in overcoming cancer drug resistance: A comprehensive review
P Maleki Dana, F Sadoughi, Z Asemi… - Cellular & molecular …, 2022 - Springer
Chemotherapeutic drugs are used to treat advanced stages of cancer or following surgery.
However, cancers often develop resistance against drugs, leading to failure of treatment and …
However, cancers often develop resistance against drugs, leading to failure of treatment and …
Recent advances in understanding the pathogenesis of rheumatoid arthritis: new treatment strategies
Rheumatoid arthritis (RA) is considered a chronic systemic, multi-factorial, inflammatory, and
progressive autoimmune disease affecting many people worldwide. While patients show …
progressive autoimmune disease affecting many people worldwide. While patients show …
Curcumin and colorectal cancer: An update and current perspective on this natural medicine
W Weng, A Goel - Seminars in cancer biology, 2022 - Elsevier
Colorectal cancer (CRC) is one of most common malignancies worldwide and its incidence
is still growing. In spite of recent advances in targeted therapies, their clinical efficacy has …
is still growing. In spite of recent advances in targeted therapies, their clinical efficacy has …
Dietary polyphenols in chemoprevention and synergistic effect in cancer: Clinical evidences and molecular mechanisms of action
Background Epidemiological studies has revealed that a diet rich in fruits and vegetables
could lower the risk of certain cancers. In this setting, natural polyphenols are potent …
could lower the risk of certain cancers. In this setting, natural polyphenols are potent …
Spices for prevention and treatment of cancers
J Zheng, Y Zhou, Y Li, DP Xu, S Li, HB Li - Nutrients, 2016 - mdpi.com
Spices have been widely used as food flavorings and folk medicines for thousands of years.
Numerous studies have documented the antioxidant, anti-inflammatory and …
Numerous studies have documented the antioxidant, anti-inflammatory and …