[HTML][HTML] A molecular approach in drug development for Alzheimer's disease

S Agatonovic-Kustrin, C Kettle, DW Morton - Biomedicine & …, 2018 - Elsevier
An increase in dementia numbers and global trends in population aging across the world
prompts the need for new medications to treat the complex biological dysfunctions, such as …

Plant-derived compounds in clinical trials

A Saklani, SK Kutty - Drug discovery today, 2008 - Elsevier
Plants remain an important source of new drugs, new drug leads and new chemical entities.
The plant-based drug discovery resulted mainly in the development of anticancer and anti …

Natural products to drugs: natural product derived compounds in clinical trials

MS Butler - Natural product reports, 2005 - pubs.rsc.org
Covering: 31st December 2004Natural product and natural product-derived compounds that
are being evaluated in clinical trials or in registration (current 31 December 2004) have …

Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998–2018)

P Mishra, A Kumar, G Panda - Bioorganic & Medicinal Chemistry, 2019 - Elsevier
Alzheimer's disease (AD) is a genetically complex, progressive and irreversible
neurodegenerative disorder of the brain which involves multiple associated etiological …

[PDF][PDF] -Tropane alkaloids as medicinally useful natural products and their synthetic derivatives as new drugs.

G Grynkiewicz, M Gadzikowska - Pharmacological Reports, 2008 - if-pan.krakow.pl
Secondary metabolites of Solanaceae plants, sharing tropane skeleton as a common
structural feature, are sharply divided into two classes: tropine and ecgonine derivatives …

Acetylcholinesterase Inhibitors as Disease-Modifying Therapies for Alzheimer s Disease

DM Torrero - Frontiers in Medicinal Chemistry: Volume 7, 2015 - benthamdirect.com
The therapeutic arsenal for the treatment of Alzheimer s disease (AD) remains confined to a
group of four inhibitors of AChE and one NMDA receptor antagonist, which are used to …

Precision medicine in Alzheimer's disease: An origami paper-based electrochemical device for cholinesterase inhibitors

V Caratelli, A Ciampaglia, J Guiducci… - Biosensors and …, 2020 - Elsevier
In the overall scenario of precision medicine, we propose a novel paper-based lab-on-a-
chip to deliver a cost-effective and easy to use sensing tool for customized administration of …

Carbamate group as structural motif in drugs: A review of carbamate derivatives used as therapeutic agents

A Matošević, A Bosak - Archives of Industrial Hygiene and Toxicology, 2020 - sciendo.com
Due to their very good chemical and proteolytic stability, ability to penetrate cell membranes,
and resemblance to a peptide bond, carbamate derivatives have received much attention in …

Muscarinic receptor subtype pharmacology and physiology

RM Eglen - Progress in medicinal chemistry, 2005 - Elsevier
Publisher Summary The role of muscarinic receptors is highly complex. The recent
pharmacological evidence with novel compounds, together with data from transgenic mice …

Recent advancements in the field of nanotechnology for the delivery of anti-Alzheimer drug in the brain region

M Agrawal, S Saraf, S Saraf… - Expert opinion on …, 2018 - Taylor & Francis
Introduction: Brain is supposed to be the most complicated part of the body which is very far
from the reach of drug moieties. The drug entry in to the brain region depends upon various …