A functional immune system requires the selection of T lymphocytes expressing receptors
that are major histocompatibility complex restricted but tolerant to self-antigens. This …

Epithelial surfaces line the body and provide a crucial interface between the body and the
external environment. Tissue-resident epithelial γδ T cells represent a major T cell …

Innate immunity is a semi‐specific and widely distributed form of immunity, which represents
the first line of defence against pathogens. This type of immunity is critical to maintain …

The gut immune system has the challenge of responding to pathogens while remaining
relatively unresponsive to food antigens and the commensal microflora. In the developed …

Commensal microflora (normal microflora, indigenous microbiota) consists of those micro-
organisms, which are present on body surfaces covered by epithelial cells and are exposed …

The unconventional T cell compartment encompasses a variety of cell subsets that straddle
the line between innate and adaptive immunity, often reside at mucosal surfaces and can …

Migration to intestinal mucosa putatively depends on local activation because
gastrointestinal lymphoid tissue induces expression of intestinal homing molecules …

The third edition of Flow Cytometry Guidelines provides the key aspects to consider when
performing flow cytometry experiments and includes comprehensive sections describing …

Friendly and dangerous signals: is the tissue in control? | Nature Immunology Skip to main
content Thank you for visiting nature.com. You are using a browser version with limited support …

γδ intraepithelial T lymphocytes (IEL) represent a major T cell population within the intestine
of unclear functional relevance. The role of intestinal γδ IEL was evaluated in the dextran …