There have been several major outbreaks of emerging viral diseases, including Hendra,
Nipah, Marburg and Ebola virus diseases, severe acute respiratory syndrome (SARS) and …

The coevolution of host-pathogen interactions underlies many human physiological traits
associated with protection from or susceptibility to infections. Among the mechanisms that …

Bats are distinctive among mammals due to their ability to fly, use laryngeal echolocation,
and tolerate viruses. However, there are currently no reliable cellular models for studying bat …

In humans, SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is highly
infective, often causes severe acute and/or long-term illness, and elicits a high rate of …

Bats are special in their ability to live long and host many emerging viruses. Our previous
studies showed that bats have altered inflammasomes, which are central players in aging …

Background Wear particles-induced osteolysis is a major long-term complication after total
joint arthroplasty. Up to now, there is no effective treatment for wear particles-induced …

Identifying virus characteristics associated with the largest public health impacts on human
populations is critical to informing “zoonotic risk” assessments and surveillance strategies …

Bats harbor high-impact zoonotic viruses often in the absence of disease manifestation. This
restriction and disease tolerance possibly rely on specific immunological features. In-depth …

Innate immune signaling pathways comprise multiple proteins that promote inflammation.
This multistep means of information transfer suggests that complexity is a prerequisite for …

The interferon pathway is the first line of defense in viral infection in all mammals, and its
induction stimulates broad expression of interferon-stimulated genes (ISGs). In mice and …