Protein aggregation occurs as a consequence of perturbations in protein homeostasis that
can be triggered by environmental and cellular stresses. The accumulation of protein …

Bacteria encounter reactive oxygen species (ROS) as a consequence of the aerobic life or
as an oxidative burst of activated neutrophils during infections. In addition, bacteria are …

Members of the AAA+ protein superfamily contribute to many diverse aspects of protein
homeostasis in prokaryotic cells. As a fundamental component of numerous proteolytic …

Intracellular proteolysis carried out by energy-dependent proteases is one of the most
conserved biological processes. In all cells proteolysis maintains and shapes the cellular …

The foodborne pathogen Listeria monocytogenes can modulate its transcriptome and
proteome to ensure its survival during transmission through vastly differing environmental …

The spore-forming bacterium and model prokaryotic genetic system, Bacillus subtilis, is
extremely useful in the study of oxidative stress management through proteomic and …

Fast adaptation to environmental changes ensures bacterial survival, and proteolysis
represents a key cellular process in adaptation. The Clp protease system is a multi …

Listeria monocytogenes is an environmental saprophyte and facultative intracellular
bacterial pathogen with a well-defined life-cycle that involves escape from a phagosome …

The transcriptional regulator Spx plays a key role in maintaining the redox homeostasis of
Bacillus subtilis cells exposed to disulfide stress. Defects in Spx were previously shown to …

Listeriolysin O (LLO) is a pore-forming toxin that mediates phagosomal escape and cell-to-
cell spread of the intracellular pathogen Listeria monocytogenes. In order to identify factors …