Transforming growth factor-β1 (TGF-β1) is considered as a crucial mediator in tissue fibrosis
and causes tissue scarring largely by activating its downstream small mother against …

Liver fibrosis is a reversible wound-healing process aimed at maintaining organ integrity,
and presents as the critical pre-stage of liver cirrhosis, which will eventually progress to …

The TGF-β signaling pathway plays a crucial role in several key aspects of development and
tissue homeostasis. TGF-β ligands and their mediators have been shown to be important …

TGF-β is a pleiotropic cytokine that regulates a wide range of cellular actions and
pathophysiological processes. TGF-β signaling is spatiotemporally fine-tuned. As a key …

Increasing evidence supports the idea that cancer cell plasticity promotes metastasis and
tumor recurrence, resulting in patient mortality. While it is clear that the tumor …

To understand the molecular mechanism of rectal cancer and develop markers for disease
prognostication, we generated and explored a dataset from 243 rectal cancer patients by …

Transforming growth factor-β (TGF-β) is a key factor in cancer development and progression.
TGF-β can suppress tumorigenesis by inhibiting cell cycle progression and stimulating …

Emerging evidence indicates that irisin provides beneficial effects in diabetes. However,
whether irisin influences the development of diabetic cardiomyopathy (DCM) remains …

Simple Summary Pancreatic cancer is aggressive and lethal with a five year survival rate of
only 5–9%. While the exact pathogenesis of pancreatic cancer is not fully understood, oral …

Objective The objective of this study was to detect the expression of MiR-21-5p in non-small-
cell lung cancer (NSCLC) tissues, and to investigate the effect of its expression on the …