Over the past two decades a growing body of evidence has demonstrated an important role
of tight junction (TJ) proteins in the physiology and disease biology of GI and liver disease …

Hepatitis B virus (HBV), an enveloped partially double-stranded DNA virus, is a widespread
human pathogen responsible for more than 250 million chronic infections worldwide …

Hepatitis C virus (HCV) is a major cause of liver disease, but therapeutic options are limited
and there are no prevention strategies. Viral entry is the first step of infection and requires …

Hepatitis C virus (HCV) is an important human pathogen that causes hepatitis, liver cirrhosis
and hepatocellular carcinoma. It imposes a serious problem to public health in the world as …

Hepatocytes, like other epithelia, are situated at the interface between the organism's
exterior and the underlying internal milieu and organize the vectorial exchange of …

Hypoxia inducible transcription factors (HIFs) activate diverse pathways that regulate cellular
metabolism, angiogenesis, proliferation, and migration, enabling a cell to respond to a low …

Hepatocellular carcinoma is one of the most prevalent and lethal cancers with limited
therapeutic options. Pathogenesis of this disease involves tumor hypoxia and the activation …

Liver disease is a growing global health problem, as deaths from end-stage liver cirrhosis
and cancer are rising across the world. At present, pharmacologic approaches to effectively …

Generation of human organoids from induced pluripotent stem cells (iPSCs) offers exciting
possibilities for developmental biology, disease modelling and cell therapy. Significant …

Hepatitis C virus (HCV) is a hepatotropic virus and a major cause of chronic hepatitis and
liver disease worldwide. Initial interactions between HCV virions and hepatocytes are …