Acute myeloid leukaemia: a paradigm for the clonal evolution of cancer?
Acute myeloid leukaemia (AML) is an uncontrolled clonal proliferation of abnormal myeloid
progenitor cells in the bone marrow and blood. Advances in cancer genomics have revealed …
progenitor cells in the bone marrow and blood. Advances in cancer genomics have revealed …
Fate map** and quantitation of hematopoiesis in vivo
T Höfer, K Busch, K Klapproth… - Annual review of …, 2016 - annualreviews.org
Hematopoietic stem cells (HSCs) and downstream progenitors have long been studied
based on phenotype, cell purification, proliferation, and transplantation into myeloablated …
based on phenotype, cell purification, proliferation, and transplantation into myeloablated …
Targeted disruption of Zfp36l2, encoding a CCCH tandem zinc finger RNA-binding protein, results in defective hematopoiesis
DJ Stumpo, HE Broxmeyer, T Ward… - Blood, The Journal …, 2009 - ashpublications.org
Members of the tristetraprolin family of tandem CCCH finger proteins can bind to AU-rich
elements in the 3′-untranslated region of mRNAs, leading to their deadenylation and …
elements in the 3′-untranslated region of mRNAs, leading to their deadenylation and …
Tcf7 is an important regulator of the switch of self-renewal and differentiation in a multipotential hematopoietic cell line
A critical problem in biology is understanding how cells choose between self-renewal and
differentiation. To generate a comprehensive view of the mechanisms controlling early …
differentiation. To generate a comprehensive view of the mechanisms controlling early …
[HTML][HTML] Identification and characterization of cancer initiating cells from BRCA1 related mammary tumors using markers for normal mammary stem cells
It is hypothesized that cancer stem cells arise either from normal stem cells or from
progenitor cells that have gained the ability to self-renew. Here we determine whether …
progenitor cells that have gained the ability to self-renew. Here we determine whether …
Phytochemical modulation of apoptosis and autophagy: Strategies to overcome chemoresistance in leukemic stem cells in the bone marrow microenvironment
Advances in scientific research and targeted treatment regimes have improved survival rates
for many cancers over the past few decades. However, for some types of leukemia, including …
for many cancers over the past few decades. However, for some types of leukemia, including …
Tel1/ETV6 specifies blood stem cells through the agency of VEGF signaling
The regulation of stem cell ontogeny is poorly understood. We show that the leukemia-
associated Ets transcription factor, Tel1/ETV6, specifies the first hematopoietic stem cells …
associated Ets transcription factor, Tel1/ETV6, specifies the first hematopoietic stem cells …
Haematopoietic development and HSC formation in vitro: promise and limitations of gastruloid models
L Dijkhuis, A Johns, D Ragusa… - Emerging Topics in …, 2023 - portlandpress.com
Haematopoietic stem cells (HSCs) are the most extensively studied adult stem cells. Yet, six
decades after their first description, reproducible and translatable generation of HSC in vitro …
decades after their first description, reproducible and translatable generation of HSC in vitro …
Concise review: asymmetric cell divisions in stem cell biology
F Murke, S Vitoriano da Conceição Castro, B Giebel… - Symmetry, 2015 - mdpi.com
Somatic stem cells are rare cells with unique properties residing in many organs and
tissues. They are undifferentiated cells responsible for tissue regeneration and homeostasis …
tissues. They are undifferentiated cells responsible for tissue regeneration and homeostasis …
Global gene expression reveals a set of new genes involved in the modification of cells during erythroid differentiation
Objectives: Erythroid differentiation is a dynamic process in which a pluripotent stem cell
undergoes a series of developmental changes that commit it to a specific lineage. These …
undergoes a series of developmental changes that commit it to a specific lineage. These …