Ageing and age-related diseases share some basic mechanistic pillars that largely
converge on inflammation. During ageing, chronic, sterile, low-grade inflammation—called …

Having made substantial progress understanding molecules, cells, genes and pathways,
aging biology research is now moving toward integration of these parts, attempting to …

The immune system is the most important protective physiological system of the organism. It
has many connections with other systems and is, in fact, often considered as part of the …

Executive summary Asthma is responsible for considerable global morbidity and health-care
costs. Substantial progress was made against key outcomes such as hospital admissions …

Aging is characterized by a morpho-functional adaptation, variably affecting major
physiological systems, depending on a complex interaction between genetic, environmental …

Abstract Growth differentiation factor 15 (GDF15) is recently emerging not only as a stress-
related mitokine, but also as a key player in the aging process, being one of the most up …

Owing to its memory and plasticity, the immune system (IS) is capable of recording all the
immunological experiences and stimuli it was exposed to. The combination of type, dose …

Recent studies uncovered important core/periphery network structures characterizing
complex sets of cooperative and competitive interactions between network nodes, be they …

Human aging is a very complex process that occurs in an intricate biological and
physiological setting. Many changes occur with aging and among the most important are …

The continued increase in global life expectancy predicts a rising prevalence of age-related
cerebral small vessel diseases (CSVD), which requires a better understanding of the …