Microphysiological systems (MPSs) are cellular models that replicate aspects of organ and
tissue functions in vitro. In contrast with conventional cell cultures, MPSs often provide …

Abstract Organ‐on‐a‐chip (OOC) platforms recapitulate human in vivo‐like conditions more
realistically compared to many animal models and conventional two‐dimensional cell …

Current in vitro antitumor drug screening strategies insufficiently mimic biological systems.
They tend to lack true perfusion and draining microcirculation systems, which may post …

Epithelial ovarian cancer has the highest mortality rate of any gynecologic malignancy and
most frequently metastasizes to the peritoneal cavity. Intraperitoneal metastases are highly …

Despite enormous advances, cardiovascular disorders are still a major threat to global
health and are responsible for one-third of deaths worldwide. Research for new therapeutics …

This review describes recent research that has advanced our understanding of the role of
immune cells in the tumor microenvironment (TME) using advanced 3D in vitro models and …

Three-dimensional (3D) visualization of tumor vasculature is a key factor in accurate
evaluation of RNA interference (RNAi)-based antiangiogenic nanomedicine, a promising …

Microfluidic organ-on-a-chip designs are used to mimic human tissues, including the
vasculature. Here we present a novel microfluidic device that allows the interaction of …

Impaired lymphatic drainage and lymphedema are major morbidities whose mechanisms
have remained obscure. To study lymphatic drainage and its impairment, we engineered a …

Breast tumor progression is a complex process involving intricate crosstalk between the
primary tumor and its microenvironment. In the context of breast tumor‐lymphatic …