Broad-spectrum pan-genus and pan-family virus vaccines

CW Tan, SA Valkenburg, LLM Poon, LF Wang - Cell Host & Microbe, 2023 - cell.com
Although the development and clinical application of SARS-CoV-2 vaccines during the
COVID-19 pandemic demonstrated unprecedented vaccine success in a short time frame, it …

Advancements in Nipah virus treatment: Analysis of current progress in vaccines, antivirals, and therapeutics

G Mishra, V Prajapat, D Nayak - Immunology, 2024 - Wiley Online Library
Nipah virus (NiV) causes severe encephalitis in humans. Three NiV strains NiV‐Malaysia
(NiVM), NiV Bangladesh (NiVB), and NiV India (NiVI reported in 2019) have been circulating …

[HTML][HTML] Learning from prepandemic data to forecast viral escape

NN Thadani, S Gurev, P Notin, N Youssef, NJ Rollins… - Nature, 2023 - nature.com
Effective pandemic preparedness relies on anticipating viral mutations that are able to
evade host immune responses to facilitate vaccine and therapeutic design. However, current …

Therapeutic administration of a cross-reactive mAb targeting the fusion glycoprotein of Nipah virus protects nonhuman primates

L Zeitlin, RW Cross, C Woolsey, BR West… - Science Translational …, 2024 - science.org
No licensed vaccines or therapies exist for patients infected with Nipah virus (NiV), although
an experimental human monoclonal antibody (mAb) cross-reactive to the NiV and Hendra …

Architecture and antigenicity of the Nipah virus attachment glycoprotein

Z Wang - Biophysical Journal, 2022 - cell.com
Nipah virus (NiV) and Hendra virus (HeV) are highly pathogenic zoonotic henipaviruses
(HNVs) responsible for recurrent outbreaks of encephalitis and respiratory illness. As the …

Principles and practical applications of structure-based vaccine design

PO Byrne, JS McLellan - Current Opinion in Immunology, 2022 - Elsevier
Highlights•Summary of the basic principles of structure-based vaccine design.•Review of
recent advances (the years 2019–2021) in structure-based vaccine design.•Preview of …

Measures to prevent and treat Nipah virus disease: research priorities for 2024–29

KA Moore, AJ Mehr, JT Ostrowsky, AK Ulrich… - The Lancet Infectious …, 2024 - thelancet.com
Nipah virus causes highly lethal disease, with case-fatality rates ranging from 40% to 100%
in recognised outbreaks. No treatments or licensed vaccines are currently available for the …

Structure and antigenicity of divergent Henipavirus fusion glycoproteins

A Isaacs, YS Low, KL Macauslane, J Seitanidou… - Nature …, 2023 - nature.com
In August 2022, a novel henipavirus (HNV) named Langya virus (LayV) was isolated from
patients with severe pneumonic disease in China. This virus is closely related to Mòjiāng …

A neutralizing antibody prevents postfusion transition of measles virus fusion protein

DS Zyla, R Della Marca, G Niemeyer, G Zipursky… - Science, 2024 - science.org
Measles virus (MeV) presents a public health threat that is escalating as vaccine coverage in
the general population declines and as populations of immunocompromised individuals …

Chimeric fusion (F) and attachment (G) glycoprotein antigen delivery by mRNA as a candidate Nipah vaccine

RJ Loomis, AT DiPiazza, S Falcone… - Frontiers in …, 2021 - frontiersin.org
Nipah virus (NiV) represents a significant pandemic threat with zoonotic transmission from
bats-to-humans with almost annual regional outbreaks characterized by documented human …