Cancer evolution: Darwin and beyond
Clinical and laboratory studies over recent decades have established branched evolution as
a feature of cancer. However, while grounded in somatic selection, several lines of evidence …
a feature of cancer. However, while grounded in somatic selection, several lines of evidence …
A practical guide to cancer subclonal reconstruction from DNA sequencing
Subclonal reconstruction from bulk tumor DNA sequencing has become a pillar of cancer
evolution studies, providing insight into the clonality and relative ordering of mutations and …
evolution studies, providing insight into the clonality and relative ordering of mutations and …
[HTML][HTML] Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution
Tumor evolution is driven by the progressive acquisition of genetic and epigenetic
alterations that enable uncontrolled growth and expansion to neighboring and distal tissues …
alterations that enable uncontrolled growth and expansion to neighboring and distal tissues …
Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics
K Morita, F Wang, K Jahn, T Hu, T Tanaka… - Nature …, 2020 - nature.com
Clonal diversity is a consequence of cancer cell evolution driven by Darwinian selection.
Precise characterization of clonal architecture is essential to understand the evolutionary …
Precise characterization of clonal architecture is essential to understand the evolutionary …
Computational immunogenomic approaches to predict response to cancer immunotherapies
Cancer immunogenomics is an emerging field that bridges genomics and immunology. The
establishment of large-scale genomic collaborative efforts along with the development of …
establishment of large-scale genomic collaborative efforts along with the development of …
Refining colorectal cancer classification and clinical stratification through a single-cell atlas
Background Colorectal cancer (CRC) consensus molecular subtypes (CMS) have different
immunological, stromal cell, and clinicopathological characteristics. Single-cell …
immunological, stromal cell, and clinicopathological characteristics. Single-cell …
Therapy sculpts the complex interplay between cancer and the immune system during tumour evolution
K Thol, P Pawlik, N McGranahan - Genome Medicine, 2022 - Springer
Cancer development is an evolutionary process. A key selection pressure is exerted by
therapy, one of the few players in cancer evolution that can be controlled. As such, an …
therapy, one of the few players in cancer evolution that can be controlled. As such, an …
Reconstructing phylogenetic trees from genome-wide somatic mutations in clonal samples
Phylogenetic trees are a powerful means to display the evolutionary history of species,
pathogens and, more recently, individual cells of the human body. Whole-genome …
pathogens and, more recently, individual cells of the human body. Whole-genome …
SCARLET: single-cell tumor phylogeny inference with copy-number constrained mutation losses
A small number of somatic mutations drive the development of cancer, but all somatic
mutations are markers of the evolutionary history of a tumor. Prominent methods to construct …
mutations are markers of the evolutionary history of a tumor. Prominent methods to construct …
CellPhy: accurate and fast probabilistic inference of single-cell phylogenies from scDNA-seq data
We introduce CellPhy, a maximum likelihood framework for inferring phylogenetic trees from
somatic single-cell single-nucleotide variants. CellPhy leverages a finite-site Markov …
somatic single-cell single-nucleotide variants. CellPhy leverages a finite-site Markov …