The centromere is a chromosomal locus that ensures delivery of one copy of each
chromosome to each daughter at cell division. Efforts to understand the nature and …

Ceulemans, Hugo, and Mathieu Bollen. Functional Diversity of Protein Phosphatase-1, a
Cellular Economizer and Reset Button. Physiol Rev 84: 1–39, 2004; 10.1152/physrev …

Abstract The Aurora kinase Ipl1p plays a crucial role in regulating kinetochore-microtubule
attachments in budding yeast, but the underlying basis for this regulation is not known. To …

The cyclin dependent kinase Cdk1 controls the cell cycle, which is best understood in the
model organism S. cerevisiae. Research performed during the past decade has significantly …

We present an analysis of over 1,100 of the∼ 10,000 predicted proteins encoded by the
genome sequence of the filamentous fungus Neurospora crassa. Seven major areas of …

Kinetochores are multicomponent assemblies that connect chromosomal centromeres to
mitotic-spindle microtubules. The Ndc80 complex is an essential core element of …

The propagation of all organisms depends on the accurate and orderly segregation of
chromosomes in mitosis and meiosis. Budding yeast has long served as an outstanding …

Mitotic chromosome segregation requires that kinetochores attach to microtubule polymers
and harness microtubule dynamics to drive chromosome movement. In budding yeast, the …

Little is known about how chromatin folds in its native state. Using optimized in situ
hybridization and live imaging techniques have determined compaction ratios and fiber …

How kinetochore proteins form a dynamic interface with microtubules is largely unknown. In
budding yeast, the 10-protein Dam1 complex is an Aurora kinase target that plays essential …