The intermediate filament (IF) cytoskeleton supports cellular structural integrity, particularly
in response to mechanical stress. The most abundant IF proteins in mature cardiomyocytes …

Considering the worldwide impact of heart failure, it is crucial to develop approaches that
can help us comprehend its root cause and make accurate predictions about its outcome …

RNA splicing is an important RNA processing step required by multiexon protein-coding
mRNAs and some noncoding RNAs. Precise RNA splicing is required for maintaining gene …

Vinculin (VCL) is a key adapter protein located in force-bearing costamere complexes,
which mechanically couples the sarcomere to the ECM. Heterozygous vinculin frameshift …

The transmembrane proteoglycan syndecan-4 is known to be involved in the hypertrophic
response to pressure overload. Although multiple downstream signaling pathways have …

The sarcomere is the fundamental contractile unit in skeletal muscle, and the regularity of its
structure is critical for function. Emerging data demonstrates that nanoscale changes to the …

Desmin, the most abundant intermediate filament in cardiomyocytes, plays a key role in
maintaining cardiomyocyte structure by interconnecting intracellular organelles, and …

Ischemic heart disease is the leading cause of death worldwide. Reduced oxygen supply
and myocardial hypoxia lead to tissue damage and impairment of the heart function. To the …

Heart failure with preserved ejection fraction (HFpEF) is characterized by biomechanically
dysfunctional cardiomyocytes. Underlying cellular changes include perturbed myocardial …

Cardiac disorders exhibit considerable heterogeneity, and understanding their genetic
foundations is crucial for their diagnosis and treatment. Recent genetic analyses involving a …