Abstract Haem oxygenase 1 (HO-1), an inducible enzyme responsible for the breakdown of
haem, is primarily considered an antioxidant, and has long been overlooked by …

Joint conditions pose an important public health problem as they are a leading cause of
pain, functional limitation and physical disability. Oxidative stress is related to the …

The death of cardiomyocytes either through apoptosis or necroptosis is the pathological
feature of cardiac ischemia-reperfusion (I/R) injury. Phosphoglycerate mutase 5 (PGAM5), a …

Impaired wound healing is one of the major complications of diabetes, involving prolonged
inflammation, delayed re-epithelialization, and consistent oxidative stress. The detailed …

Nrf2 is a key transcription factor responsible for antioxidant defense in many tissues and
cells, including alveolar epithelium, endothelium, and macrophages. Furthermore, Nrf2 …

Phenolic acids are found in natural plants, such as caffeic acid, rosmarinic acid, and
chlorogenic acid. They have long been used as pharmacological actives, owing to their anti …

Abstract Coronavirus disease 2019 (COVID-19) is a recent pandemic caused by a novel
severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) leading to pulmonary and …

Along with the impressive achievements in understanding the endogenous signaling roles
and mechanism (s) of action of carbon monoxide (CO), much research has demonstrated …

Nature has endowed gaseous molecules such as O 2, CO 2, CO, NO, H 2 S, and N 2 with
critical and diverse roles in sustaining life, from supplying energy needed to power life and …

Obesity-mediated metabolic syndrome remains the leading cause of death worldwide.
Among many potential targets for pharmacological intervention, a promising strategy …