Single-cell omics: experimental workflow, data analyses and applications
Cells are the fundamental units of biological systems and exhibit unique development
trajectories and molecular features. Our exploration of how the genomes orchestrate the …
trajectories and molecular features. Our exploration of how the genomes orchestrate the …
Applications of single-cell technologies in drug discovery for tumor treatment
B Liu, S Hu, X Wang - Iscience, 2024 - cell.com
Single-cell technologies have been known as advanced and powerful tools to study tumor
biological systems at the single-cell resolution and are playing increasingly critical roles in …
biological systems at the single-cell resolution and are playing increasingly critical roles in …
Luminal breast epithelial cells of BRCA1 or BRCA2 mutation carriers and noncarriers harbor common breast cancer copy number alterations
The prevalence and nature of somatic copy number alterations (CNAs) in breast epithelium
and their role in tumor initiation and evolution remain poorly understood. Using single-cell …
and their role in tumor initiation and evolution remain poorly understood. Using single-cell …
Normal breast tissues harbour rare populations of aneuploid epithelial cells
Aneuploid epithelial cells are common in breast cancer,; however, their presence in normal
breast tissues is not well understood. To address this question, we applied single-cell DNA …
breast tissues is not well understood. To address this question, we applied single-cell DNA …
Progression from ductal carcinoma in situ to invasive breast cancer: molecular features and clinical significance
J Wang, B Li, M Luo, J Huang, K Zhang… - … and Targeted Therapy, 2024 - nature.com
Ductal carcinoma in situ (DCIS) represents pre-invasive breast carcinoma. In untreated
cases, 25–60% DCIS progress to invasive ductal carcinoma (IDC). The challenge lies in …
cases, 25–60% DCIS progress to invasive ductal carcinoma (IDC). The challenge lies in …
Single Nucleus Total RNA Sequencing of Formalin‐Fixed Paraffin‐Embedded Gliomas
Gliomas, the predominant form of brain cancer, comprise diverse malignant subtypes with
limited curative therapies available. The insufficient understanding of their molecular …
limited curative therapies available. The insufficient understanding of their molecular …
High clonal diversity and spatial genetic admixture in early prostate cancer and surrounding normal tissue
Somatic copy number alterations (SCNAs) are pervasive in advanced human cancers, but
their prevalence and spatial distribution in early-stage, localized tumors and their …
their prevalence and spatial distribution in early-stage, localized tumors and their …
Injectable nano-in situ-thermosensitive-hydrogels based on halofuginone and silver for postoperative treatment against triple-negative breast cancer
R Zuo, J Gong, X Gao, E Nepovimova, J Zhang… - International Journal of …, 2024 - Elsevier
Postoperative distant metastasis and high recurrence rate causes a dilemma in treating
triple-negative breast cancer (TNBC) owing to its unforeseeable invasion into various …
triple-negative breast cancer (TNBC) owing to its unforeseeable invasion into various …
Serial single-cell RNA sequencing unveils drug resistance and metastatic traits in stage IV breast cancer
Metastasis is a complex process that remains poorly understood at the molecular levels. We
profiled single-cell transcriptomic, genomic, and epigenomic changes associated with …
profiled single-cell transcriptomic, genomic, and epigenomic changes associated with …
Conquering Overtreatment of DCIS: Lessons from PRECISION
As we cannot reliably distinguish indolent, low-risk ductal carcinoma in situ (DCIS) from
potentially progressive, high-risk DCIS, all women with DCIS diagnosis undergo intensive …
potentially progressive, high-risk DCIS, all women with DCIS diagnosis undergo intensive …