Ageing leads to profound alterations in the immune system and increases susceptibility to
some chronic, infectious and autoimmune diseases. In recent years, widespread application …

Immune system aging is characterized by the paradox of immunosenescence (insufficiency)
and inflammaging (over-reaction), which incorporate two sides of the same coin, resulting in …

The cytokine IL-7 and its receptor, IL-7R, are critical for T cell and, in the mouse, B cell
development, as well as differentiation and survival of naive T cells, and generation and …

Neuroinflammation in patients with Alzheimer's disease (AD) and related mouse models has
been recognized for decades, but the contribution of the recently described meningeal …

IL-17A–producing γδ T cells in mice consist primarily of Vγ6+ tissue-resident cells and Vγ4+
circulating cells. How these γδ T cell subsets are regulated during homeostasis and cancer …

γδ T cells have recently gained considerable attention as an attractive tool for cancer
adoptive immunotherapy due to their potent anti-tumor activity and unique role in …

Research on tumor‐associated neutrophils (TAN) currently surges because of the well‐
documented strong clinical relevance of tumor‐infiltrating neutrophils. This relevance is …

Unconventional T cells include γδ T cells, invariant Natural Killer T cells (iNKT) cells and
Mucosal Associated Invariant T (MAIT) cells, which are distinguished from conventional T …

Summary γδ T cells comprise the third cell lineage of lymphocytes that use, like αβ T cells
and B cells, V (D) J gene rearrangement with the potential to generate a highly diverse T cell …

Skin aging is characterized by structural and functional changes that contribute to age-
associated frailty. This probably depends on synergy between alterations in the local niche …