[HTML][HTML] Techniques of using circulating tumor DNA as a liquid biopsy component in cancer management
M Elazezy, SA Joosse - Computational and structural biotechnology journal, 2018 - Elsevier
Precision medicine in the clinical management of cancer may be achieved through the
diagnostic platform called “liquid biopsy”. This method utilizes the detection of biomarkers in …
diagnostic platform called “liquid biopsy”. This method utilizes the detection of biomarkers in …
A phase Ib trial of personalized neoantigen therapy plus anti-PD-1 in patients with advanced melanoma, non-small cell lung cancer, or bladder cancer
PA Ott, S Hu-Lieskovan, B Chmielowski, R Govindan… - Cell, 2020 - cell.com
Neoantigens arise from mutations in cancer cells and are important targets of T cell-
mediated anti-tumor immunity. Here, we report the first open-label, phase Ib clinical trial of a …
mediated anti-tumor immunity. Here, we report the first open-label, phase Ib clinical trial of a …
Review of current methods, applications, and data management for the bioinformatics analysis of whole exome sequencing
The advent of next-generation sequencing technologies has greatly promoted advances in
the study of human diseases at the genomic, transcriptomic, and epigenetic levels. Exome …
the study of human diseases at the genomic, transcriptomic, and epigenetic levels. Exome …
Integrative analysis identifies four molecular and clinical subsets in uveal melanoma
Comprehensive multiplatform analysis of 80 uveal melanomas (UM) identifies four
molecularly distinct, clinically relevant subtypes: two associated with poor-prognosis …
molecularly distinct, clinically relevant subtypes: two associated with poor-prognosis …
Personalized neoantigen vaccine NEO-PV-01 with chemotherapy and anti-PD-1 as first-line treatment for non-squamous non-small cell lung cancer
Neoantigens arising from mutations in tumor DNA provide targets for immune-based
therapy. Here, we report the clinical and immune data from a Phase Ib clinical trial of a …
therapy. Here, we report the clinical and immune data from a Phase Ib clinical trial of a …
The integrated genomic landscape of thymic epithelial tumors
Thymic epithelial tumors (TETs) are one of the rarest adult malignancies. Among TETs,
thymoma is the most predominant, characterized by a unique association with autoimmune …
thymoma is the most predominant, characterized by a unique association with autoimmune …
Identifying Mendelian disease genes with the variant effect scoring tool
Background Whole exome sequencing studies identify hundreds to thousands of rare
protein coding variants of ambiguous significance for human health. Computational tools are …
protein coding variants of ambiguous significance for human health. Computational tools are …
A drosophila genetic resource of mutants to study mechanisms underlying human genetic diseases
Invertebrate model systems are powerful tools for studying human disease owing to their
genetic tractability and ease of screening. We conducted a mosaic genetic screen of lethal …
genetic tractability and ease of screening. We conducted a mosaic genetic screen of lethal …
[HTML][HTML] Genes that affect brain structure and function identified by rare variant analyses of Mendelian neurologic disease
Development of the human nervous system involves complex interactions among
fundamental cellular processes and requires a multitude of genes, many of which remain to …
fundamental cellular processes and requires a multitude of genes, many of which remain to …
[HTML][HTML] A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing
As whole-genome sequencing for cancer genome analysis becomes a clinical tool, a full
understanding of the variables affecting sequencing analysis output is required. Here using …
understanding of the variables affecting sequencing analysis output is required. Here using …