Importance The incidence of early-onset colorectal cancer (younger than 50 years) is rising
globally, the reasons for which are unclear. It appears to represent a unique disease …

Over the past several decades, the incidence of early-onset colorectal cancer (EOCRC; in
patients< 50 years old) has increased at an alarming rate. Although robust and scientifically …

The human gut is home to a large and diverse microbial community, comprising about 1,000
bacterial species. The gut microbiota exists in a symbiotic relationship with its host, playing a …

Mucins are the gatekeepers of the mucosal barrier of the gastrointestinal tract and are
aberrantly expressed in various gastrointestinal pathologies, including pathogen infection …

Colorectal cancer (CRC) is the third leading cause of cancer-related mortality in men or
women in the United States. Average-risk screening that begins at age 50 years has …

The critical role of the gut microbiome in gastrointestinal cancers is becoming increasingly
clear. Imbalances in the gut microbial community, referred to as dysbiosis, are linked to …

Emerging evidence suggests that gut microbiota may influence the response to
chemotherapy. We sought to characterize the effects of 5 fluorouracil (5FU) chemotherapy …

Background & Aims The Western diet, which is high in fat, is a modifiable risk factor for
colorectal recurrence after curative resection. We investigated the mechanisms by which the …

The gut microbiome (GMB) plays a substantial role in human health and disease. From
affecting gut barrier integrity to promoting immune cell differentiation, the GMB is capable of …

Colorectal cancer (CRC) is now one of the leading causes of cancer incidence and mortality.
Although nanomaterial-based drug delivery has been used for the treatment of colorectal …