New molecular, cellular, and immunologic techniques used to study host–pathogen
interactions have led to a reexamination of the role of infection in chronic obstructive …

Despite anti-retroviral therapy (ART), human immunodeficiency virus-1 (HIV)-related
pulmonary disease continues to be a major cause of morbidity and mortality for people living …

Cigarette smoke exposure is the major cause of chronic obstructive pulmonary disease
(COPD). However, only a minority of smokers develop significant COPD, and patients with …

Rationale: In aging HIV-infected populations comorbid diseases are important determinants
of morbidity and mortality. Pulmonary diseases have not been systematically assessed in …

Tuberculosis (TB), smoking, HIV and chronic obstructive pulmonary disease (COPD) are
burgeoning epidemics in develo** countries. The link between TB and HIV is well …

Background Limited data prior to highly active antiretroviral therapy (HAART) suggested the
possibility of an increased risk of COPD among those persons with HIV infection. We sought …

Chronic inflammation containing CD8+ lymphocytes, neutrophils, and macrophages, and
pulmonary emphysema coexist in lungs from patients with chronic obstructive pulmonary …

Airway inflammation is central to the pathogenesis of both airway remodelling and
parenchymal destruction in chronic obstructive pulmonary disease (COPD). Neutrophils …

Patients present with symptoms. Doctors are trained to recognise disease. There is no better
illustration of these two different paradigms than cough. Unfortunately for the patient, the …

The lung is a site for repeated or chronic inflammatory insults. Epidemiologic research has
provided evidence to support the hypothesis that tissue damage caused by inflammation …