Genetic architecture of ADHD and overlap with other psychiatric disorders and cognition-related phenotypes

M Ribasés, M Mitjans, CA Hartman, MS Artigas… - Neuroscience & …, 2023 - Elsevier
Attention-deficit/hyperactivity disorder (ADHD) co-occurs with many other psychiatric
disorders and traits. In this review, we summarize and interpret the existing literature on the …

An integrated framework for local genetic correlation analysis

J Werme, S van der Sluis, D Posthuma, CA de Leeuw - Nature genetics, 2022 - nature.com
Genetic correlation (rg) analysis is used to identify phenotypes that may have a shared
genetic basis. Traditionally, rg is studied globally, considering only the average of the …

Role of the gut-brain axis in the shared genetic etiology between gastrointestinal tract diseases and psychiatric disorders: a genome-wide pleiotropic analysis

W Gong, P Guo, Y Li, L Liu, R Yan, S Liu… - JAMA …, 2023 - jamanetwork.com
Importance Comorbidities and genetic correlations between gastrointestinal tract diseases
and psychiatric disorders have been widely reported, with the gut-brain axis (GBA) …

Benchmarking of local genetic correlation estimation methods using summary statistics from genome-wide association studies

C Zhang, Y Zhang, Y Zhang… - Briefings in Bioinformatics, 2023 - academic.oup.com
Local genetic correlation evaluates the correlation of additive genetic effects between
different traits across the same genetic variants at a genomic locus. It has been proven …

Multi-trait and cross-population genome-wide association studies across autoimmune and allergic diseases identify shared and distinct genetic component

Y Shirai, Y Nakanishi, A Suzuki, H Konaka… - Annals of the Rheumatic …, 2022 - Elsevier
Objectives Autoimmune and allergic diseases are outcomes of the dysregulation of the
immune system. Our study aimed to elucidate differences or shared components in genetic …

Genetic relationships between attention-deficit/hyperactivity disorder, autism spectrum disorder, and intelligence

S Rao, A Baranova, Y Yao, J Wang, F Zhang - Neuropsychobiology, 2022 - karger.com
Introduction: Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder
(ASD) commonly co-occur; both traits exert an influence on intelligence scores. Genetic …

[HTML][HTML] mtPGS: Leverage multiple correlated traits for accurate polygenic score construction

C Xu, SK Ganesh, X Zhou - The American Journal of Human Genetics, 2023 - cell.com
Accurate polygenic scores (PGSs) facilitate the genetic prediction of complex traits and aid
in the development of personalized medicine. Here, we develop a statistical method called …

Discovering non-additive heritability using additive GWAS summary statistics

SP Smith, G Darnell, D Udwin, J Stamp, A Harpak… - Elife, 2024 - elifesciences.org
LD score regression (LDSC) is a method to estimate narrow-sense heritability from genome-
wide association study (GWAS) summary statistics alone, making it a fast and popular …

Insights into the genetic architecture of cerebellar lobules derived from the UK Biobank

A Carrión-Castillo, C Boeckx - Scientific Reports, 2024 - nature.com
In this work we endeavor to further understand the genetic architecture of the cerebellum by
examining the genetic underpinnings of the different cerebellar lob (ul) es, identifying their …

Genetic control of abiotic stress-related specialized metabolites in sunflower

M Moroldo, N Blanchet, H Duruflé, S Bernillon, T Berton… - BMC genomics, 2024 - Springer
Background Abiotic stresses in plants include all the environmental conditions that
significantly reduce yields, like drought and heat. One of the most significant effects they …