Metabolomics-centered mining of plant metabolic diversity and function: Past decade and future perspectives

S Shen, C Zhan, C Yang, AR Fernie, J Luo - Molecular Plant, 2023 - cell.com
Plants are natural experts in organic synthesis, being able to generate large numbers of
specific metabolites with widely varying structures that help them adapt to variable survival …

Metabolomics toward personalized medicine

M Jacob, AL Lopata, M Dasouki… - Mass spectrometry …, 2019 - Wiley Online Library
Metabolomics, which is the metabolites profiling in biological matrices, is a key tool for
biomarker discovery and personalized medicine and has great potential to elucidate the …

Metabolomics for plant improvement: status and prospects

R Kumar, A Bohra, AK Pandey, MK Pandey… - Frontiers in Plant …, 2017 - frontiersin.org
Post-genomics era has witnessed the development of cutting-edge technologies that have
offered cost-efficient and high-throughput ways for molecular characterization of the function …

An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders

NJ Ashton, A Hye, AP Rajkumar, A Leuzy… - Nature Reviews …, 2020 - nature.com
Cerebrospinal fluid analyses and neuroimaging can identify the underlying pathophysiology
at the earliest stage of some neurodegenerative disorders, but do not have the scalability …

Gut microenvironmental changes as a potential trigger in Parkinson's disease through the gut–brain axis

SJ Chen, CH Lin - Journal of biomedical science, 2022 - Springer
Parkinson's disease (PD) is the second most common neurodegenerative disease attributed
to the synergistic effects of genetic risk and environmental stimuli. Although PD is …

Alpha-synuclein as a biomarker of Parkinson's disease: good, but not good enough

U Ganguly, S Singh, S Pal, S Prasad… - Frontiers in aging …, 2021 - frontiersin.org
Parkinson's disease (PD) is the second most common neurodegenerative disorder of the
elderly, presenting primarily with symptoms of motor impairment. The disease is diagnosed …

Investigating casual associations among gut microbiota, metabolites, and neurodegenerative diseases: a Mendelian randomization study

J Ning, SY Huang, SD Chen, YR Zhang… - Journal of …, 2022 - content.iospress.com
Background: Recent studies had explored that gut microbiota was associated with
neurodegenerative diseases (including Alzheimer's disease (AD), Parkinson's disease (PD) …

Update on CSF biomarkers in Parkinson's disease

EH Kwon, S Tennagels, R Gold, K Gerwert, L Beyer… - Biomolecules, 2022 - mdpi.com
Progress in develo** disease-modifying therapies in Parkinson's disease (PD) can only
be achieved through reliable objective markers that help to identify subjects at risk. This …

Biomarkers in motor neuron disease: a state of the art review

NS Verber, SR Shepheard, M Sassani… - Frontiers in …, 2019 - frontiersin.org
Motor neuron disease can be viewed as an umbrella term describing a heterogeneous
group of conditions, all of which are relentlessly progressive and ultimately fatal. The …

Plasma branched-chain and aromatic amino acids correlate with the gut microbiota and severity of Parkinson's disease

Y Zhang, X He, Y Qian, S Xu, C Mo, Z Yan… - npj Parkinson's …, 2022 - nature.com
Disturbances of circulating amino acids have been demonstrated in patients with
Parkinson's disease (PD). However, there have been no consistent results for branched …