Increasing evidence indicates that the tumor microenvironment has critical roles in all
aspects of cancer biology, including growth, angiogenesis, metastasis and progression …

The delineation of key molecular pathways has enhanced our knowledge of the biology of
tumor microenvironment, tumor dissemination, and carcinogenesis. The complexities of cell …

CXCR4 is a pleiotropic chemokine receptor which acts through its ligand CXCL12 to
regulate diverse physiological processes. CXCR4/CXCL12 axis plays a pivotal role in …

Genetic engineering T cells to create clinically applied chimeric antigen receptor (CAR) T
cells has led to improved patient outcomes for some forms of hematopoietic malignancies …

Ovarian carcinoma is the fifth common cause of cancer death in women, despite advanced
therapeutic approaches. αvβ3 integrin, a plasma membrane receptor, binds thyroid …

The CXCR 4/CXCR 7/CXCL 12 chemokine axis plays important roles in the migration of
tumor cells during cancer development by modulating site‐specific distant metastasis …

After oncogenic transformation, tumor cells rewire their metabolism to obtain sufficient
energy and biochemical building blocks for cell proliferation, even under hypoxic conditions …

The current study aimed to investigate the potential role of miR-9 in the inhibition of ovarian
cancer progression through the stromal cell-derived factor-1 (SDF‑1)/C‑X‑C chemokine …

Compared with noninvasive tumor cells, glioma cells overexpress chemokine receptor type
4 (CXCR4), which exhibits significantly greater expression in invasive tumor cells than in …

Endometrial cancer is the most common gynecological cancer, representing 3.5% of all new
cancer cases in the United States. Abnormal stem cell-like cells, referred to as cancer stem …